Behavioral characterization of mild cognitive impairment
Behavioral characterization of mild cognitive impairment
复制标题
DOI：
10.1076/jcen.24.6.720.8397
复制
发表时间：
2002-09-01
影响因子：
2.2
通讯作者：
Currie, J
中科院分区：
文献类型：
--
作者：
Collie, A;Maruff, P;Currie, J
最近对老年人轻度认知障碍（MCI）的行为和遗传结果的调查结果不一致。这些相互矛盾的结果可能归因于所采用的诊断系统的研究之间的差异，以及使用不可靠的神经心理学测量。根据新的标准，我们调查了被归类为轻度认知障碍的老年人的行为和遗传结果，该标准需要在三个连续的神经/神经心理学评估中提供认知障碍的证据。174名健康老年人每半年接受一次评估，为期12个月。其中，23名受试者在连续三次评估中被评为轻度认知障碍，并与23名匹配的对照受试者进行比较。在三个半年度评估中的一个或两个中被评为受损的受试者也被确定。MCI组和匹配的对照组在一系列行为测量上进行了比较。测定载脂蛋白E4 （ApoE4）等位基因在所有组中的患病率，并获得焦虑和抑郁症状的估计。主观认知抱怨也被评估。许多受试者在一项或两项评估中被归类为受损，但相对较少（n=23）记录了持续的认知缺陷。在MCI受试者中观察到的最严重的损害是在模式定位联想学习测试中，然而MCI受试者并没有意识到这种损害。ApoE4等位基因的患病率在匹配的对照组和MCI组之间没有差异。这些结果表明，MCI个体可以与健康老年人和有短暂性认知障碍的老年人区分开来，但这种区分需要对认知功能进行一系列评估。
Results from recent investigations of behavioral and genetic outcomes in older people with mild cognitive impairment (MCI) have been inconsistent. These conflicting results may be attributed to between-study differences in the diagnostic systems employed, as well as the use of unreliable neuropsychological measures. We investigated behavioral and genetic outcomes in older people classified as having MCI according to novel criterion that required evidence of cognitive impairment on three consecutive neurological/neuropsychological assessments. One hundred and seventy four healthy older people were evaluated semi-annually for 12 months. Of these, 23 subjects were rated as having MCI on three consecutive assessments and were compared to 23 matched control subjects. Subjects rated as impaired on one or two of the three semi-annual assessments were also identified. MCI and matched control groups were compared on a range of behavioral measures. The prevalence of the Apolipoprotein E4 (ApoE4) allele was determined in all groups, and estimates of anxiety and depressive symptomatology were obtained. Subjective cognitive complaints were also assessed. Many subjects were classified as impaired on one or two assessments, however relatively few (n=23) recorded consistent cognitive deficits. The most severe impairment observed in MCI subjects was on a test of pattern-location associative learning, however MCI subjects did not have insight into this impairment. The prevalence of the ApoE4 allele was not different between matched control and MCI groups. These results indicate that individuals with MCI can be differentiated from healthy older people and older people with transient cognitive impairments, but that such differentiation requires serial assessment of cognitive function.