The Rodent Model of Glaucoma and Its Implications
The Rodent Model of Glaucoma and Its Implications
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DOI：
10.1097/apo.0000000000000122
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发表时间：
2015-07-01
影响因子：
4.4
通讯作者：
Zhang, Xiulan
中科院分区：
文献类型：
--
作者：
Chen, Shida;Zhang, Xiulan
青光眼是一组进行性视神经病变，其特征是视网膜神经节细胞变性，与眼压水平等因素有关。青光眼的确切发病机制尚不清楚，目前的治疗方案不足以预防或恢复青光眼患者的视力丧失。因此，需要功能性的、可重复的和易于使用的动物模型。由于其固有的优势，啮齿类动物，包括小鼠和大鼠，已被广泛开发为研究青光眼的各个方面和评估可能的新疗法的模型。然而，没有一个单一的模型已被证明可以模拟青光眼的所有方面。在这篇综述中，我们讨论了目前可用的啮齿动物模型的青光眼，他们的优点和缺点，以及目前青光眼研究的可能影响。
Glaucoma is a group of progressive optic neuropathies, characterized by the degeneration of retinal ganglion cells related to the level of intraocular pressure and other factors. The exact pathogenesis of glaucoma is not known, and current therapeutic options are not sufficient to prevent or recover vision loss in glaucoma patients. Functional, repeatable, and easy-to-use animal models are therefore needed. Because of their inherent advantages, rodent animals, including mice and rats, have been widely developed as models to study various aspects of glaucoma and to evaluate possible novel therapies. However, no single model has been shown to emulate all aspects of glaucoma. In this review, we discuss currently available rodent animal models of glaucoma, their strengths and weaknesses, and the possible implications for current glaucoma research.