PLASMA-LIPIDS IN HIV-INFECTED PATIENTS - A PROSPECTIVE-STUDY IN 95 PATIENTS
PLASMA-LIPIDS IN HIV-INFECTED PATIENTS - A PROSPECTIVE-STUDY IN 95 PATIENTS
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DOI：
10.1111/j.1365-2362.1994.tb02185.x
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发表时间：
1994-06-01
影响因子：
5.5
通讯作者：
CONRI, C
中科院分区：
文献类型：
--
作者：
CONSTANS, J;PELLEGRIN, JL;CONRI, C
本研究的目的是确定95例HIV感染者的血脂水平分为四组，根据CD 4淋巴细胞计数比较对照组的20个HIV阴性normolipidaemic主题。此外，还研究了糖尿病异常与免疫或营养状况之间的关系。CD 4淋巴细胞小于200 mm（-3）的患者（第1组和第2组）的总胆固醇显著低于对照组。低于400个CD 4淋巴细胞mm（-3）的患者（第1、2、3组）的甘油三酯和Lp（a）显著高于对照组，而LDL-胆固醇显著低于对照组。在所有HIV阳性患者中，无论其CD 4淋巴细胞计数如何，HDL-C和apoA 1均低于对照组。通过多变量分析，甘油三酯与急性机会性感染和干扰素-α水平呈正相关，而胆固醇与TNF-α呈负相关，LDL-C与白蛋白血症呈正相关。后一个参数是唯一与营养标志物相关的营养价值。污染途径，或存在的浪费，是不相关的任何dodic疾病。
The present study aimed to determine plasma lipid levels in 95 HIV-infected patients divided into four groups according to the CD4 lymphocyte counts comparatively to a control group of 20 HIV-negative normolipidaemic subjects. A relationship between lipidic abnormalities and immune or nutritional status was also investigated. The patients below 200 CD4 lymphocyte mm(-3) (groups 1 and 2) had significantly lower total cholesterol than the controls. The patients below 400 CD4 lymphocytes mm(-3) (groups 1, 2, 3) had significantly higher triglycerides and Lp(a) but lower LDL-cholesterol than the controls. In all HIV-positive patients, whatever their CD4 lymphocyte count, HDL-C and apoA1 were lower than in the controls. By multivariate analysis triglycerides were positively correlated to acute opportunistic infections and to interferon-alpha levels, while cholesterol was negatively correlated to TNF-alpha, and LDL-C was positively correlated to albuminaemia. The latter parameter was the only lipidic value to correlate with nutritional markers. The contamination route, or the presence of wasting, was not correlated to any lipidic disorder.