Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting.
Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting.
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DOI：
10.1177/0300060518762949
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Iwama T
中科院分区：
文献类型：
--
作者：
Tsujimoto M;Enomoto Y;Miyai M;Egashira Y;Iwama T
确定颈动脉支架植入术（CAS）后支架内组织突出的最佳血小板功能试验。在这项观察性研究中前瞻性招募了接受CAS的患者。术前给予阿司匹林100 mg/天和氯吡格雷75 mg/天联合用药至少7天。在用二磷酸腺苷（ADP）、胶原蛋白和凝血酶受体活化肽（TRAP）刺激后，通过透光率聚集测定法（LTA）和即时检测法（VerifyNow）（测量阿司匹林和噻吩并吡啶反应单位）测量血小板聚集。光学相干断层扫描（OCT）在10/28例（36%）患者中检测到最大投影面积≥1 mm 2的支架内组织突出。两个支架内尺寸组之间的基线特征无显著差异（即，≥1 mm 2与<1 mm 2），但在10和20 μg/ml胶原刺激后，通过LTA测量的血小板反应性在≥1 mm 2组中显著高于<1 mm 2组。未检测到血小板功能的其他差异。胶原诱导的血小板反应性与CAS后支架内组织突起大小相关。
To determine the best platelet function test for in-stent tissue protrusion following carotid artery stenting (CAS). Patients who underwent CAS were recruited prospectively in this observational study. Combination of aspirin 100 mg/day and clopidogrel 75 mg/day was administered for a minimum of 7 days prior to procedure. Platelet aggregation was measured by light transmittance aggregometry (LTA) following stimulation by adenosine diphosphate (ADP), collagen, and thrombin receptor activating peptide (TRAP) and by the point of care assay, VerifyNow which measures aspirin and thienopyridine reaction units. In-stent tissue protrusion with maximum projection area of ≥1 mm2 was detected by optical coherence tomography (OCT) in 10/28 (36%) patients. Baseline characteristics were not significantly different between the two in-stent size groups (i.e., ≥1 mm2 vs. <1 mm2) but after stimulation by collagen at 10 and 20 μg/ml, platelet reactivity as measured by LTA was significantly higher in the ≥1 mm2 group compared with the <1 mm2 group. No other differences in platelet function were detected. Collagen-induced platelet reactivity was related to in-stent tissue protrusion size following CAS.
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在MR血管造影上表现出高强度信号的糖尿病和颈动脉斑块与颈动脉支架后血小板反应性的增加有关。
影响因子：
4.8
作者：
Tsujimoto M;Enomoto Y;Kokuzawa J;Iwama T
通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
158.5
作者：
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通讯作者：
Montalescot, Gilles