Colloidal gold nanoparticles: A novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors
Colloidal gold nanoparticles: A novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors
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DOI：
10.1002/ddr.20066
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发表时间：
2006-01-01
影响因子：
3.8
通讯作者：
Tamarkin, Lawrence
中科院分区：
文献类型：
--
作者：
Paciotti, Giulio F.;Kingston, David G. I.;Tamarkin, Lawrence
应用于生物问题的纳米技术代表了一个新兴领域，有可能提供极其敏感的诊断和靶向癌症治疗。然而，为了实现这些目标，纳米颗粒递送系统必须战胜身体防御固有的许多障碍，以及在肿瘤生长和进展过程中形成的障碍。科学正在进步，例如，真正的纳米级肿瘤靶向药物递送载体现在能够降低血液中调理作用和网状内皮系统吸收的可能性。其他进展有望将多种治疗剂递送至实体瘤中的非同质癌细胞群。我们在此简要总结了我们使用胶体金纳米颗粒构建这种多功能纳米治疗剂的尝试。具体来说，我们讨论了胶体金为基础的药物，旨在针对实体瘤的TNF和紫杉醇的交付的发展。
Nanotechnology applied to biological problems represents an emerging field with the potential to offer extremely sensitive diagnostics and targeted cancer therapies. However, to achieve these goals, nanoparticle delivery systems must outwit the many barriers that are intrinsic to the body's defenses, as well as those that develop during the growth and progression of tumors. The science is advancing and, for example, true nanoscale tumor-targeted drug delivery vectors are now able to reduce the likelihood of opsonization in the bloodstream and uptake by the reticuloendothelial system. Other advances hold promise for delivering multiple therapeutic agents to non-homogeneous populations of cancer cells in solid tumors. We briefly summarize herein our attempts to build such multifunctional nanotherapeutics using colloidal gold nanoparticles. Specifically we discuss the development of colloidal gold-based drugs that are designed to target the delivery of TNF and paclitaxel to solid tumors.