Target-controlled differentiation of axon terminals and synaptic organization.
Target-controlled differentiation of axon terminals and synaptic organization.
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轴突末端和突触组织的目标控制分化。
DOI：
10.1073/pnas.84.19.6929
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发表时间：
1987
影响因子：
11.1
通讯作者：
Frost,DO
中科院分区：
文献类型：
--
作者：
Campbell,G;Frost,DO
这些实验研究了调节突触连接形态分化的过程。电子显微镜观察发现，丘脑视主核-膝状背外侧核的视网膜传入轴突的终末轴突和突触复合体与丘脑体感觉主核(腹基底核)的上升传入轴突的形态不同。金黄地鼠发育中的视网膜神经节细胞轴突被永久性地投射到腹基底核，而不是外侧膝状核。就所观察的大多数超微结构特征而言，成熟的顺行标记的视网膜-腹基底轴突的终末和突触复合体比外侧膝状核内的正常视网膜分离轴突更接近于腹基底核的正常躯体感觉传入。这些结果表明，轴突终末和突触复合体的超微结构分化在很大程度上受靶环境的调节，尽管一些特征似乎是传入轴突本身固有的。
These experiments investigate the processes regulating the morphological differentiation of synaptic connections. Electron microscopy showed that the terminal boutons and synaptic complexes of retinal afferent axons in the main thalamic visual nucleus, the dorsal lateral geniculate nucleus, differ in their morphology from those of ascending afferent axons in the main thalamic somatosensory (ventrobasal) nucleus. Developing retinal ganglion cell axons in hamsters were made to project permanently to the ventrobasal nucleus, rather than to the lateral geniculate nucleus. With respect to most of the ultrastructural features examined, the terminals and synaptic complexes of mature, anterogradely labeled retino-ventrobasal axons more closely resembled those of normal somatosensory afferents to the ventrobasal nucleus than they did those of normal retinofugal axons within the lateral geniculate nucleus. These results suggest that the ultrastructural differentiation of axon terminals and synaptic complexes is regulated largely by the target environment, although some features appear to be intrinsic to the afferent axons themselves.