Nanoengineered polymer capsules:: Tools for detection, controlled delivery, and site-specific manipulation
Nanoengineered polymer capsules:: Tools for detection, controlled delivery, and site-specific manipulation
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DOI：
10.1002/smll.200400075
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发表时间：
2005-02-01
期刊：
影响因子：
13.3
通讯作者：
Parak, WJ
中科院分区：
文献类型：
--
作者：
Sukhorukov, GB;Rogach, AL;Parak, WJ
纳米生物技术的跨学科领域融合了许多学科。其中一个目标是发现新的药物及其输送系统，例如，建立多功能胶囊作为智能药物载体：一旦注射到血液中的某个地方，胶囊就会找到它们的目标，修复或杀死受损的细胞，报告诊断结果，然后离开该部位，而不会造成任何进一步的损害。这样的承诺似乎只能是科幻小说的主题，但实际上它正在成为一个现实的项目，当然，这仍然需要广泛的创新。在实验方面，纳米和微载体的制造和工程及其后续功能化已经取得了很大进展。下一步是将不同的功能整合到一个载体中，从而提供新型的输送系统。这将通过引导载体到指定类型的细胞或组织来实现更有效的药物运输。此外，这种载体还可以监测pH值条件或温度，并在外部触发下，在预定义的位置启动化学反应。专门设计和封装的材料和表面将有助于提高特异性，降低总药物浓度，减少副作用。这样的系统将为控制药物递送到细胞或组织的特定部位提供一种工具。在其他领域，例如在植入学和组织工程中，由于药物的缓慢释放支持愈合和整合的可能性，载体系统引起了人们的兴趣。
The interdisciplinary field of nanobiotechnology merges a number of disciplines. One aim is the discovery of new drugs and their delivery systems, as for example to build up multifunctional capsules as intelligent drug carriers: once injected somewhere into the bloodstream the capsules would find their target, repair or kill the damaged cells, report the diagnostics, and leave the site without any further damage. It seems that such promises could only be a subject for science fiction but in fact it is becoming a realistic project, which, of course, still requires a wide range of innovations. On the experimental side much progress has been achieved in the fabrication and engineering of nano- and microcarriers and their subsequent functionalization. The next step is to combine different functions into one carrier, thus providing new types of delivery systems. This would allow for more efficient drug transport by guiding the carriers to designated types of cells or tissues. Furthermore, such carriers could also monitor the pH conditions or the temperature and, upon external triggering, start a chemical reaction at a predefined site. Specifically designed and encapsulated materials and surfaces would contribute to improved specificity and allow a reduction in total drug concentration with fewer side-effects. Such systems would provide a tool for the controlled delivery of drugs to cells or specific parts of tissue. In other areas, for instance in implantology and tissue engineering, carrier systems are of interest due to the possibility of the slow release of drugs to support healing and integration.