Probing cells with noble metal nanoparticle aggregates.
Probing cells with noble metal nanoparticle aggregates.
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DOI：
10.2217/17435889.3.4.555
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发表时间：
2008-08
期刊：
影响因子：
5.5
通讯作者：
Maryuri Roca;A. Haes
中科院分区：
文献类型：
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作者：
Maryuri Roca;A. Haes
本文综述了贵金属纳米颗粒聚集体作为标记物和转运容器在细胞应用中的整合。纳米颗粒聚集的自然趋势可以通过表面改性来降低;然而，这种稳定性通常在细胞环境中受到损害。纳米颗粒聚集的程度具有积极和消极的后果。与单个纳米颗粒相比，纳米颗粒聚集体更有效地被生物体去除，从而阻止递送至其细胞靶点。此外，这些聚集体被细胞以与孤立的纳米颗粒不同的方式识别。尽管有这些负面影响，与单个纳米颗粒相比，聚集体表现出许多检测和治疗技术的增强。在未来几年中，聚集体的作用和更好地控制聚集程度的细胞研究将需要实现医疗应用。
This review focuses on the integration of noble metal nanoparticle aggregates as tags and transport vessels in cellular applications. The natural tendency of nanoparticles to aggregate can be reduced through surface modification; however, this stabilization is often compromised in the cellular environment. The degree of nanoparticle aggregation has both positive and negative consequences. Nanoparticle aggregates are more efficiently removed by the organism compared with single nanoparticles, preventing delivery to their cellular target. In addition, these aggregates are recognized by cells in different ways versus isolated nanoparticles. Despite these negatives, aggregates exhibit enhancement for many detection and treatment techniques in comparison with single nanoparticles. In coming years, the role of aggregates and better control over the degree of aggregation in cellular studies will be required for the realization of medical applications.