Increased hepatic lipid peroxidation with methionine toxicity in the rat.
Increased hepatic lipid peroxidation with methionine toxicity in the rat.
复制标题
大鼠体内蛋氨酸毒性增加肝脂质过氧化。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
J. Strain
中科院分区：
文献类型：
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作者：
S. M. Lynch;J. Strain
已知大鼠摄入过量的蛋氨酸会导致膜损伤、肝脏肿大和脾脏中铁的积累。在这项研究中，两组 (n = 5) 雄性 Wistar 大鼠配对喂养补充蛋氨酸 (20.0 g/kg) 或对照 (2.0 g/kg) 饮食 7 周。补充蛋氨酸后，肝脏和红细胞铜锌超氧化物歧化酶活性显着降低（P分别小于0.05和P小于0.001），过氧化氢酶（P小于0.01和0.05）和谷胱甘肽过氧化物酶（P小于0.05）活性显着增加。补充蛋氨酸还增加了肝脏脂质过氧化（P 小于 0.01），通过硫代巴比妥酸反应物质的水平和铁（P 小于 0.001）浓度来测量。这些变化表明蛋氨酸毒性导致氧化应激增加。
Consumption of excess methionine by rats is known to cause membrane damage, liver enlargement and accumulation of iron in the spleen. In this study two groups (n = 5) of male, Wistar rats were pair-fed either a methionine supplemented (20.0 g/kg) or control (2.0 g/kg) diet for 7 weeks. Hepatic and erythrocyte copper-zinc superoxide dismutase activities were significantly reduced (P less than 0.05 and P less than 0.001 respectively) by methionine supplementation while the activities of catalase (P less than 0.01 and 0.05) and glutathione peroxidase (P less than 0.05) were significantly increased. Methionine supplementation also increased hepatic lipid peroxidation (P less than 0.01), as measured by the level of thiobarbituric acid reactive substances, and iron (P less than 0.001) concentrations. These changes are indicative of increased oxidative stress resulting from methionine toxicity.
影响因子：
15.9
作者：
STARKEBAUM, G;HARLAN, JM
通讯作者：
HARLAN, JM