While a phobic waits: Regional brain electrical and autonomic activity in social phobics during anticipation of public speaking
While a phobic waits: Regional brain electrical and autonomic activity in social phobics during anticipation of public speaking
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DOI：
10.1016/s0006-3223(99)00222-x
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发表时间：
2000-01-15
影响因子：
10.6
通讯作者：
Henriques, JB
中科院分区：
文献类型：
--
作者：
Davidson, RJ;Marshall, JR;Henriques, JB
背景：最近的研究强调了右侧颞叶前部和前额叶前部在焦虑期间的作用，但没有研究对社交恐惧症进行区域大脑和自主神经功能的评估。这项研究比较了社交恐惧症患者和控制者在准备发表公开演讲时的脑电图和自主神经活动。方法：记录18例DSM-IV版社交恐惧症患者和10例正常人在演讲前和演讲后的14个头皮部位的脑电图、心率和血压。还获得了焦虑和情绪的自我报告。结果：在期待条件下，恐惧症患者的焦虑和负面情绪明显高于对照组。在大多数情况下，恐惧症患者的心率都比对照组高。恐惧症患者的右侧颞叶前部和前额叶外侧区域的激活明显增加。在预期阶段，这些心率和脑电图变化共同占负性情绪增加方差的48%。结论：这些发现支持焦虑期间右侧前皮层激活的假设，并表明预期期间脑电图和心率变化的结合解释了报告的负面影响的实质性差异。(C) 2000年生物精神病学学会。
Background: Recent studies have highlighted the role of right-sided anterior temporal and prefrontal activation during anxiety, yet no study has been performed with social phobics that assesses regional brain and autonomic function. This study compared electroencephalograms (EEGs) and autonomic activity in social phobics and controls while they anticipated making a public speech.Methods: Electroencephalograms from 14 scalp locations, heart rate, and blood pressure were recorded while 18 DSM-IV social phobics and 10 controls anticipated making a public speech, as well as immediately after the speech was made. Self-reports of anxiety and affect were also obtained.Results: Phobics showed a significantly greater increase in anxiety and negative affect during the anticipation condition compared with controls. Heart rate was elevated in the phobics relative to the controls in most conditions. Phobics showed a marked increase in right-sided activation in the anterior temporal and lateral prefrontal scalp regions. These heart rate and EEG changes together accounted for > 48% of the variance in the increase in negative affect during the anticipation phase.Conclusions: These findings support the hypothesis of right-sided anterior cortical activation during anxiety and indicate that the combination of EEG and heart rate changes during anticipation account for substantial variance in reported negative affect. (C) 2000 Society of Biological Psychiatry.