Construction of a blood-compatible interface based on surface segregation in a polymer blend
Construction of a blood-compatible interface based on surface segregation in a polymer blend
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DOI：
10.1016/j.polymer.2015.10.001
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发表时间：
2015-11
期刊：
影响因子：
4.6
通讯作者：
T. Hirata;H. Matsuno;D. Kawaguchi;N. Yamada;Masaru Tanaka;Keiji Tanaka
中科院分区：
文献类型：
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作者：
T. Hirata;H. Matsuno;D. Kawaguchi;N. Yamada;Masaru Tanaka;Keiji Tanaka
采用表面离析技术制备了生物惰性聚合物界面。在基质聚合物中加入少量具有良好生物惰性的聚丙烯酸2-甲氧乙酯(PMEA)，用量为10wt%，就能有效地抑制血小板黏附，具有实际应用价值。PMEA是有效的，因为它优先在聚合物共混物的最外层区域分离。将气泡接触角和中子反射率测量、和频产生光谱等界面敏感性分析与血小板粘附性测试相结合，可以更好地了解生物惰性在水界面上的表现方式。
The technique of surface segregation was applied to prepare a bio-inert polymer interface. A small amount, 10 wt%, of poly(2-methoxyethyl acrylate) (PMEA), which exhibits excellent bio-inertness properties, fed into a matrix polymer was able to suppress platelet adhesion sufficiently to be of practical use. PMEA was effective because it was preferentially segregated at the outermost region of the polymer blend. Combining interfacial-sensitive analyses such as the air bubble contact angle and neutron reflectivity measurements and sum-frequency generation spectroscopy with the platelet adhesion test gives a better understanding of how the bio-inert property is expressed at the water interface.