Variations in Patients' Perceptions and Use of Generic Drugs: Results of a National Survey
Variations in Patients' Perceptions and Use of Generic Drugs: Results of a National Survey
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DOI：
10.1007/s11606-016-3612-7
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发表时间：
2016-06-01
影响因子：
5.7
通讯作者：
Campbell, Eric G.
中科院分区：
文献类型：
--
作者：
Kesselheim, Aaron S.;Gagne, Joshua J.;Campbell, Eric G.
在美国，超过84%的处方药是仿制药，尽管在之前的调查中，患者报告了对仿制药质量的担忧。我们的目的是调查患者对仿制药的看法和使用情况。我们的调查（2014年8月进行）评估了患者对仿制药安全性和有效性的怀疑，以及他们要求购买名牌药物的频率。卡方检验和双样本t检验评估了患者人口统计学特征与结果之间的关联。我们的样本框架是CVS顾问小组，一个包含124，621名CVS客户的国家数据库。我们随机选择了1450名自我报告的慢性病患者，他们在过去3个月内至少开了一张处方。我们评估了患者在过去一年中要求医生开品牌药而不是仿制药的频率，以及“仿制药怀疑论”，定义为不相信仿制药安全，有效，有同样的副作用，在1，442名提供有效地址的病人中，933名作出回应（回应率为65%），753名接受了全面调查。绝大多数人（83%）同意医生应该在可用时开仿制药，54%的人说他们在过去一年中没有要求医生开名牌药而不是仿制药。大多数受访者认为仿制药与品牌药一样有效（87%）和安全（88%），并且具有相同的副作用（80%）和活性成分（84%）。非白种人比白种人更有可能要求品牌药物而不是仿制药。（56%对43%，p < 0.01），也更怀疑仿制药的临床等效性（43%对29%，p < 0.01）。我们发现更多的患者对仿制药有积极的看法，但必须克服挥之不去的负面看法，以确保继续节省费用，并改善非专利药对病人的治疗效果。
Over 84 % of all prescriptions in the US are filled as generic drugs, though in prior surveys, patients reported concerns about their quality.We aimed to survey patients' perceptions and use of generic drugs.Our survey (administered August 2014) assessed patients' skepticism about generic drug safety and effectiveness and how often they requested brand-name drugs. Chi-square tests and two-sample t-tests assessed associations between patient demographics and the outcomes.Our sample frame was the CVS Advisor Panel, a national database of 124,621 CVS customers. We randomly selected 1450 patients with self-reported chronic conditions who filled at least one prescription in the prior 3 months.We assessed how often patients reported asking their physicians to prescribe a brand-name over a generic drug in the last year, and "generic skepticism," defined as not believing generic drugs were as safe, effective, had the same side effects, and contained the same active ingredients as brand-name drugs.Of the 1,442 patients with valid addresses, 933 responded (65 % response rate) and 753 took the full survey. A vast majority (83 %) agreed that physicians should prescribe generic drugs when available, and 54 % said they had not asked their physicians to prescribe a brand-name drug over a generic in the past year. Most respondents considered generic drugs to be as effective (87 %) and safe (88 %) as their brand-name counterparts, and to have the same side effects (80 %) and active ingredients (84 %). Non-Caucasians were more likely than Caucasians to request a brand-name drug over a generic (56 % vs. 43 %, p < 0.01), and were also more skeptical of generic drugs' clinical equivalence (43 % vs. 29 %, p < 0.01).We found a substantial shift towards more patients having positive views of generic drugs, but lingering negative perceptions will have to be overcome to ensure continued cost-savings and improved patient outcomes from generic drugs.