Intestinal mesenchymal cells.
Intestinal mesenchymal cells.
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DOI：
10.1007/s11894-010-0135-y
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发表时间：
2010-10
影响因子：
--
通讯作者：
Powell, D W
中科院分区：
文献类型：
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作者：
Pinchuk, I V;Mifflin, R C;Saada, J I;Powell, D W
肠固有层的非白细胞间充质成分是肌成纤维细胞、成纤维细胞、周细胞、基质干细胞、粘膜肌层和与淋巴管相关的绒毛核心平滑肌。我们回顾了这些间充质细胞的功能解剖学、关于它们在胚胎中的起源和在成人中的替代的已知信息、它们在肠粘膜形态发生中的假定作用以及肠干细胞生态位，并且我们考虑了关于肌成纤维细胞作为非专业免疫细胞的新信息。尽管我们对间充质细胞在肠道疾病中的功能的了解还很初级，但我们在此简要考虑它们在癌症和肠道炎症中的作用。
The non–white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. We review the functional anatomy of these mesenchymal cells, what is known about their origin in the embryo and their replacement in adults, their putative role in intestinal mucosal morphogenesis, and the intestinal stem cell niche, and we consider new information about myofibroblasts as nonprofessional immune cells. Although our knowledge of the function of mesenchymal cells in intestinal disease is rudimentary, we briefly consider here their roles in cancer and intestinal inflammation.