Ambulation-promoting effect of peppermint oil and identification of its active constituents
Ambulation-promoting effect of peppermint oil and identification of its active constituents
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DOI：
10.1016/s0091-3057(01)00543-3
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发表时间：
2001-07-01
影响因子：
3.6
通讯作者：
Ito, H
中科院分区：
文献类型：
--
作者：
Umezu, T;Sakata, A;Ito, H
传统上，尽管缺乏科学证据，各种植物精油(Eos)仍被用于治疗精神障碍。在之前的一项研究中，我们证明了某些Eos具有行为效应，这一发现支持了我们最初的假设，即Eos具有精神活性行为。进行这项研究是为了获得更多的证据来支持我们的假设。薄荷油是EO的一种，被认为对治疗精神疲劳有效。当给ICR小鼠腹腔注射该油时，小鼠的行走活动显著增加。经GC-MS分析，确定了薄荷油的组成成分为α-品烯、β-品烯、(R)-(+)-柠檬烯、1，8-桉叶醇、异薄荷酮、薄荷酮、薄荷醇、(R)-(+)-普利酮、乙酸薄荷酯和石竹烯。然后，我们检查了薄荷油的每一种成分对小鼠行走活动的影响。腹腔注射1，8-桉树醇、薄荷酮、异薄荷酮、薄荷醇、(R)-(+)-白藜芦酮、乙酸薄荷酯和石竹烯可显著增强小鼠的活动能力，提示这些化学物质是薄荷油的行为活性成分。静脉注射这些物质可显著增加小鼠的活动能力，但剂量要低得多。本研究提供了进一步的证据，证明Eos对行为具有药理作用。此外，我们的发现显示，薄荷油的作用来自其组成元素。(C)2001 Elsevier Science Inc.保留所有权利。
Various plant-derived essential oils (EOs) have traditionally been used in the treatment of mental disorders, despite a lack of scientific evidence. In a previous study, we demonstrated that certain EOs possess behavioral effects, a finding that supports our original hypotheses that EOs possess psychoactive actions. The present study was conducted in order to obtain farther evidence to support our hypothesis. Peppermint oil, a type of EO, is believed to be effective for treating mental fatigue. When the oil was administered intraperitoneally to ICR mice, the ambulatory activity of mice increased dramatically. We identified alpha -pinene, beta -pinene, (R)-(+)-limonene, 1,8-cineol, isomenthone, menthone, menthol, (R)-(+)-pulegone, menthyl acetate and caryophyllene as constituent elements of peppermint oil by GC-MS analysis. We then examined the effect of each constituent element of peppermint oil on ambulatory activity in mice. Intraperitoneal administration of 1,8-cineol, menthone, isomenthone, menthol, (R)-(+)-pulegone, menthyl acetate and caryophyllene significantly increased ambulatory activity in mice, suggesting that these chemicals are the behaviorally active elements of peppermint oil. Intravenous administration of these substances to mice induced a significant increase in ambulatory activity at much lower doses. The present study provides farther evidence demonstrating that EOs possess pharmacological actions on behavior. In addition, our finding revealed that the action of peppermint oil comes from its constituent elements. (C) 2001 Elsevier Science Inc. All rights reserved.