The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides
The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides
复制标题
DOI：
10.1038/s41589-018-0068-6
复制
发表时间：
2018-07-01
影响因子：
14.8
通讯作者：
Suessmuth, Roderich D.
中科院分区：
文献类型：
--
作者：
Wiebach, Vincent;Mainz, Andi;Suessmuth, Roderich D.
有效的抗菌羊毛硫肽microvionin，分离自Microbacterium arborescens的培养物，表现出一个新的三氨基二羧酸部分，称为avionin，和前所未有的N-末端胍基脂肪酸。我们确定了相应的生物合成基因簇，并在体外重建了鸟黄素生物合成的中心步骤。从萜烯诺卡氏菌中分离出的诺卡菌素的基因组挖掘和分离揭示了这种羊毛硫肽类的广泛分布，称为脂兰素，其可能用作未来的抗微生物药物。
The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens, exhibits a new triamino-dicarboxylic acid moiety, termed avionin, and an unprecedented N-terminal guanidino fatty acid. We identified the corresponding biosynthetic gene cluster and reconstituted central steps of avionin biosynthesis in vitro. Genome mining and isolation of nocavionin from Nocardia terpenica revealed a widespread distribution of this lanthipeptide class, termed lipolanthines, which may be useful as future antimicrobial drugs.