Mitogen stimulation of lymphocytes exposed to lead.
Mitogen stimulation of lymphocytes exposed to lead.
复制标题
暴露于铅的淋巴细胞有丝分裂原刺激。
DOI：
10.1016/0041-008x(82)90116-8
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发表时间：
1982
影响因子：
3.8
通讯作者：
D. Archer
中科院分区：
文献类型：
--
作者：
B. Blakley;D. Archer
雌性 BDF1 小鼠暴露于饮用水中浓度为 0 至 1000 ppm 铅的铅达 3 周。体外有丝分裂原研究表明，铅对 T 细胞有丝分裂原刀豆球蛋白 A、植物血凝素和葡萄球菌肠毒素 A 的活性产生剂量依赖性增强。铅不会改变 B 细胞有丝分裂原、大肠杆菌脂多糖的活性。铅和刀豆球蛋白 A 或植物血凝素之间发生显着的协同相互作用，表明铅可能影响特定的 T 细胞亚群。用葡萄球菌肠毒素 A 进行的体内有丝分裂原研究表明，铅对有丝分裂原反应没有显着影响。类似铅暴露的体内和体外有丝分裂原反应之间的比较和外推没有意义。
Female BDF1mice were exposed for 3 weeks to lead in the drinking water at concentrations ranging from 0 to 1000 ppm lead. In vitro mitogen studies demonstrated that lead produced a dose-dependent enhancement of the activity for the T-cell mitogens concanavalin A, phytohemagglutinin, and staphylococcal enterotoxin A. Lead did not alter the activity of the B-cell mitogen, Escherichia coli lipopolysaccharide. A significant synergistic interaction occurred between lead and concanavalin A or phytohemagglutinin, suggesting that lead may be affecting a specific T-cell subpopulation. In vivo mitogen studies with staphylococcal enterotoxin A demonstrated that lead has no significant effect on the mitogen response. Comparisons and extrapolations between the in vivo and in vitro mitogen responses with similar lead exposures are not meaningful.