Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era.
Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era.
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DOI：
10.1158/1940-6207.capr-10-0257
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Platz EA
中科院分区：
文献类型：
--
作者：
Joshu CE;Mondul AM;Menke A;Meinhold C;Han M;Humphreys EB;Freedland SJ;Walsh PC;Platz EA
While obesity at time of prostatectomy has been associated with prostate cancer recurrence, it is unknown whether obesity before or after surgery, or weight change from the years prior to surgery to after surgery is associated with recurrence. Thus, we examined the influence of obesity and weight change on recurrence after prostatectomy. We conducted a retrospective cohort study of 1,337 men with clinically-localized prostate cancer who underwent prostatectomy performed during 1993-2006 by the same surgeon. Men self-reported weight and physical activity at 5 years before and 1 year after surgery on a survey during follow-up. Mean follow up was 7.3 years. We estimated multivariable-adjusted hazard ratios of prostate cancer recurrence comparing obesity at 5 years before and at 1 year after surgery with normal weight, and a gain of >2.2 kg from 5 years before to 1 year after surgery with stable weight. During 9,797 person years of follow-up, 102 men recurred. Compared with men who had stable weight, those whose weight increased >2.2 kg had twice the recurrence risk (HR=1.94, 95% CI 1.14-3.32) after taking into account age, pathological stage and grade, and other characteristics. The HR of recurrence was 1.20 (95% CI 0.64-2.23) and 1.72 (95% CI 0.94-3.14) comparing obesity at 5 years before and at 1 year after surgery, respectively, with normal weight. Physical activity (≥5 hrs/wk) did not attenuate risk in men who gained >2.2 kg. By avoiding weight gain, men with prostate cancer may both prevent recurrence and improve overall well-being.
