Application of 3D printing technology for generating hollow-type suppository shells.
Application of 3D printing technology for generating hollow-type suppository shells.
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应用3D打印技术生成空心型栓剂壳。
DOI：
10.1016/j.ijpharm.2020.119825
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ozeki T.
中科院分区：
文献类型：
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作者：
Tagami T;Ito E;Hayashi N;Sakai N;Ozeki T.
在美国食品和药物管理局批准3D打印片剂（Spritam）之后，3D打印技术用于生成片剂的应用引起了制药行业的关注。在这里，我们重点关注通常由医院药剂师制备为栓剂壳的空心型栓剂制剂。我们使用熔融沉积成型型3D打印机和聚乙烯醇长丝作为水溶性材料，通过改变3D设计对象的打印条件来打印具有不同厚度和不同内部结构的栓剂外壳。栓剂外壳的硬度取决于厚度和设计的内部结构。离子液体是一种新型的液体药物制剂，其活性药物成分被装载在栓剂壳中。栓剂制剂的药物溶出曲线根据栓剂壳的类型而不同。制备复合栓剂制剂（栓剂壳中独立隔室中的两种药物），作为儿科患者的定制药物模型。我们的研究结果表明，3D打印技术适用于制备中空型栓剂制剂，并可能与现场医院生产兼容。
The application of 3D printing technology for generating tablets is attracting the attention of the pharmaceutical industry following approval of a 3D printed tablet (Spritam) by the US Food and Drug Administration. Here we focused on hollow-type suppository formulations typically prepared as suppository shells by pharmacists in hospitals. We used a fused deposition modeling-type 3D printer and polyvinyl alcohol filament as a water soluble material to print suppository shells with various thicknesses and different inner structures by changing the printing conditions for the 3D designed objects. The hardness of the suppository shell was dependent on the thickness and designed inner structure. An active pharmaceutical ingredient ionic liquid, a novel type of liquid drug formulation, was loaded in the suppository shells. The drug dissolution profile of the suppository formulations differed depending on the type of suppository shell. Composite suppository formulations (two drugs in separate compartments in the suppository shell) were prepared as a model tailored medicine for pediatric patients. Our findings suggest that 3D printing technology is applicable to the preparation of hollow-type suppository formulations and may be compatible with on-site hospital production.