Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis
Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis
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DOI：
10.1016/j.stem.2007.08.002
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发表时间：
2007-10-01
期刊：
影响因子：
23.9
通讯作者：
Jones, D. Leanne
中科院分区：
文献类型：
--
作者：
Boyle, Monica;Wong, Chihunt;Jones, D. Leanne
衰老的特征是器官和组织功能受损。干细胞数量和/或活性的减少可能会导致与衰老相关的组织稳态下降。我们已经分析了衰老过程如何影响果蝇睾丸中的生殖系干细胞(GSC)行为，并报告了干细胞微环境或利基内发生的重大变化，这些变化有助于随着时间的推移干细胞数量的下降。具体地说，老年男性睾丸中的体细胞壁龛细胞显示细胞黏附分子DE-钙粘附素的表达减少，以及一个关键的自我更新信号不成对(UPD)。UPD的丢失与驻留在利基内的干细胞的总体减少相关。相反，UPD在壁龛细胞中的强制表达维持了老年男性的GSCs。因此，我们的数据表明，干细胞内与年龄相关的变化可能是老年人组织动态平衡和再生能力下降的一个重要因素。
Aging is characterized by compromised organ and tissue function. A decrease in stem cell number and/or activity could lead to the aging-related decline in tissue homeostasis. We have analyzed how the process of aging affects germ line stem cell (GSC) behavior in the Drosophila testis and report that significant changes within the stem cell microenvironment, or niche, occur that contribute to a decline in stem cell number over time. Specifically, somatic niche cells in testes from older males display reduced expression of the cell adhesion molecule DE-cadherin and a key self-renewal signal unpaired (upd). Loss of upd correlates with an overall decrease in stem cells residing within the niche. Conversely, forced expression of upd within niche cells maintains GSCs in older males. Therefore, our data indicate that age-related changes within stem cell niches may be a significant contributing factor to reduced tissue homeostasis and regeneration in older individuals.