Cardiovascular protection by ginsenosides and their nitric oxide releasing action
Cardiovascular protection by ginsenosides and their nitric oxide releasing action
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DOI：
10.1111/j.1440-1681.1996.tb01767.x
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发表时间：
1996-08-01
影响因子：
2.9
通讯作者：
Chen, X
中科院分区：
文献类型：
--
作者：
Chen, X
1.在体内动物模型中，人参皂甙（GS）（来自人参的皂甙）被证明可以防止心肌缺血/再灌注损伤，同时增加6-酮-PGF（1 α）和减少脂质过氧化。2.在原位灌注兔肺和离体兔主动脉环中，GS保护肺和主动脉内皮免受电解诱导的自由基损伤。纯化的GS组分、Rb 1尤其是Rg 1具有舒张肺血管的作用，这种作用可被一氧化氮（NO）还原酶抑制剂硝基-L-精氨酸所消除.在培养的牛主动脉内皮细胞中，GS促进[C-14]-L-精氨酸向[C-14]-L-瓜氨酸的转化，表明NO.4的释放增加。NO是诱导阴茎勃起的神经递质，GS可促进离体兔阴茎海绵体（CC）释放NO。人参皂甙增强乙酰胆碱诱导的和透壁神经刺激激活的松弛与组织cGMP增加。后者的影响被河豚毒素消除，并与组织cGMP减少有关。人参皂苷增强的CC松弛被硝基精氨酸和氧合血红蛋白减弱，而被超氧化物歧化酶增强.据推测，GS的心血管保护作用可能部分介导的NO，一种有效的抗氧化剂的释放，并从内皮细胞，特别是从血管周围的一氧化氮能神经在CC的GS增强释放NO，可能部分占中药人参的壮阳作用。
1. In an animal model in vivo, ginsenosides (GS), saponins from Panax ginseng, were shown to protect against myocardial ischaemia/reperfusion damage with concomitant increased 6-keto-PGF(1 alpha) and decreased lipid peroxidation.2. In perfused rabbit lung in situ and isolated rabbit aortic rings, GS protected the pulmonary and aortic endothelium against electrolysis-induced free radical injury. Purified components of GS, Rb1 and especially Rg1, relaxed pulmonary vessels and this effect was eliminated by nitro-L-arginine, an inhibitor of nitric oxide (NO) synthase.3. In cultured bovine aortic endothelial cells, GS enhanced the conversion of [C-14]-L-arginine to [C-14]-L-citrulline, indicating an increased release of NO.4. As the neurotransmitter inducing penile erection, NO release was shown to be enhanced by GS in rabbit corpus cavernosum (CC) in vitro. Ginsenosides enhanced both acetylcholine-induced and transmural nerve stimulation-activated relaxation associated with increased tissue cGMP. The latter effect was eliminated by tetrodotoxin and was associated with decreased tissue cGMP. Ginsenoside-enhanced CC relaxation was attenuated by nitro-L-arginine and oxyhaemoglobin, and enhanced by superoxide dismutase.5. It is postulated that cardiovascular protection by GS may be partly mediated by the release of NO, a potent antioxidant, and that the GS-enhanced release of NO from endothelial cells, especially from perivascular nitric oxidergic nerves in the CC, may partly account for the aphrodisiac effect of Panax ginseng used in traditional Chinese medicine.