Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusitis.
Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusitis.
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长期服用克拉霉素治疗顽固性慢性鼻窦炎的疗效观察
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
S. Baba
中科院分区：
文献类型：
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作者：
M. Hashiba;S. Baba
长期红霉素治疗已被报道为有效治疗各种慢性呼吸道疾病，包括慢性鼻窦炎。我们研究了长期使用红霉素衍生物克拉霉素（CAM）治疗顽固性慢性鼻窦炎的临床疗效。45名成人患者接受了400 mg/天的剂量治疗，持续8至12周。结果如下。i）71.1%的患者症状和内窥镜检查结果改善。ii）对于长达12周的时间，临床疗效取决于治疗的持续时间。给药超过12周可能会进一步改善临床结果。iii）在CAM治疗过程中没有注意到显著的副作用。总的来说，CAM在治疗慢性鼻窦炎方面至少与红霉素一样有效。
Long-term erythromycin therapy has been reported as effective in the treatment of various chronic respiratory diseases, including chronic sinusitis. We investigated the clinical efficacy of long-term administration of the erythromycin derivative clarithromycin (CAM) in intractable cases of chronic sinusitis. Forty-five adult patients were treated with dosages of 400 mg/day for 8 to 12 weeks. The results were as follows. i) Improvement of symptoms and rhinoscopic findings was noted in 71.1% of the patients. ii) For periods of up to 12 weeks, clinical efficacy depended upon the duration of treatment. Administration for more than 12 weeks might further improve clinical results. iii) No significant side effects were noted during the course of CAM treatment. On the whole, CAM was at least as effective as erythromycin in the treatment of chronic sinusitis.