POLYMORPHISM IN ALDH2-GENOTYPE IN JAPANESE MEN AND THE ALCOHOL-BLOOD PRESSURE RELATIONSHIP
POLYMORPHISM IN ALDH2-GENOTYPE IN JAPANESE MEN AND THE ALCOHOL-BLOOD PRESSURE RELATIONSHIP
复制标题
DOI：
10.1016/0895-7061(95)00222-b
复制
发表时间：
1995-11-01
影响因子：
3.2
通讯作者：
YAMADA, Y
中科院分区：
文献类型：
--
作者：
TSURITANI, I;IKAI, E;YAMADA, Y
具有低米氏常数（K-m）的醛脱氢酶（ALDH 2）是参与乙醇的毒性代谢物乙醛在肝脏中转化为乙酸的主要酶。在一半的日本人中发现了ALDH 2活性的遗传缺陷，其特征是饮酒后的“东方潮红”。本研究的目的是评估酒精代谢的遗传多态性对酒精压力效应敏感性的影响。使用从白色血细胞中提取的基因组DNA确定了403名日本中年男性的ALDH 2基因型。243例（60%）受试者为正常ALDH 2基因纯合子，25例（6%）受试者为突变ALDH 2基因纯合子，其余135例（33%）为杂合子。没有一个突变基因的纯合子喝了足够的酒来显示酒精的压力效应。与酒精摄入量增加或血清γ-谷氨酰转肽（GTP）水平升高相关的血压升高在其他两种ALDH 2基因型之间没有差异。可以得出结论，在日本男性中发现的ALDH 2基因型的多态性不影响个体对酒精压力效应的敏感性。
Aldehyde dehydrogenase with a low Michaelis constant (K-m), ALDH2, is a major enzyme involved in the conversion of acetaldehyde, a toxic metabolite of ethanol, into acetic acid in the liver. Inherited deficiency of ALDH2 activity is found in half of Japanese, and is characterized by ''Oriental flushing'' after alcohol consumption. The aim of the present study is to evaluate the influence of the genetic polymorphism in alcohol metabolism on the sensitivity to the presser effect of alcohol. Genotypes of ALDH2 were determined in 403 middle-aged Japanese men using genomic DNA extracted from white blood cells. Two hundred and forty-three (60%) of the subjects were shown to be homozygotes for the normal ALDH2 gene, 25 (6%) of the subjects were homozygotes for the mutant ALDH2 gene, and the remaining 135 (33%) were heterozygotes. None of the homozygotes for the mutant gene drank enough to show the presser effect of alcohol. Elevations of blood pressure associated with increasing alcohol consumption or with elevations of serum gamma-glutamyl transpeptide (GTP) level were not different between the other two ALDH2-genotypes. It can be concluded that polymorphism in the ALDH2-genotype found in Japanese men does not affect the individual sensitivity to the presser effect of alcohol.