The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
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DOI：
10.1093/ajcn/63.1.116
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发表时间：
1996-01-01
影响因子：
7.1
通讯作者：
James, MJ
中科院分区：
文献类型：
--
作者：
Caughey, GE;Mantzioris, E;James, MJ
在健康志愿者中检测了亚麻籽油饮食对肿瘤坏死因子α（TNF α）和白细胞介素1 β（IL-1 β）合成的影响。在家庭食品制备中使用亚麻籽油4周可抑制TNF α和IL-1 β的产生约30%。鱼油补充剂（9 g/d）持续4周，TNF α和IL-1 β的合成分别被抑制了74%和80%。TNF α或IL-1 β合成与单核细胞二十碳五烯酸（EPA）含量之间存在显著的反指数关系，EPA是一种来自摄入EPA（鱼油）的n-3脂肪酸，或摄入Cr-亚麻酸（亚麻籽油）的代谢。当细胞EPA增加至约占总脂肪酸的1%时，细胞因子产生减少。EPA含量的进一步增加不会导致细胞因子产生的进一步减少。结果表明，富含n-3脂肪酸的植物油抑制TNF α和IL-1 β的合成。
The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers. Use of flaxseed oil in domestic food preparation for 4 wk inhibited TNF alpha and IL-1 beta production by approximate to 30%. Fish-oil supplementation (9 g/d) continued for a further 4 wk; TNF alpha and IL-1 beta synthesis were inhibited by 74% and 80%, respectively. There was a significant inverse exponential relation between TNF alpha or IL-1 beta synthesis and mononuclear cell content of eicosapentaenoic acid (EPA), an n-3 fatty acid derived from ingested EPA (fish oil) or metabolism of ingested cr-linolenic acid (flaxseed oil). Cytokine production decreased as cellular EPA increased to approximate to 1% of total fatty acids. Further increases in EPA content did not result in further decreases in cytokine production. The results indicate that vegetable oils rich in n-3 fatty acids inhibit TNF alpha and IL-1 beta synthesis.