An emerging public health threat: Mayaro virus increases its distribution in Peru
An emerging public health threat: Mayaro virus increases its distribution in Peru
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DOI：
10.1016/j.ijid.2020.01.024
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发表时间：
2020-03-01
影响因子：
8.4
通讯作者：
del Vatte, Luis J.
中科院分区：
文献类型：
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作者：
Angel Aguilar-Luis, Miguel;del Valle-Mendoza, Juana;del Vatte, Luis J.
背景：由马雅罗病毒（MAYV）引起的感染是一种被忽视的热带病，表现为急性发热性疾病。该病毒是南美洲和加勒比地区的一种地方性和新出现的病原体，导致偶尔和特征不明确的疫情。目前，关于其扩张和风险领域的信息有限。方法：2017年1月至6月在秘鲁卡哈马卡地区的10个城市初级保健卫生中心进行横断面研究。共对359例疑似发热性疾病患者进行评估。从血清样品中提取RNA，然后进行MAYV实时逆转录酶PCR （RT-PCR）检测nsP1基因。结果：经RT-PCR扩增和验证性DNA测序，11.1%（40/359）的样品检出MAYV。大多数感染发生在18-39岁（40%）和40-59岁（32.5%）的成年人群中。头痛是MAYV感染患者最常见的症状（77.5%），其次是发热（72.5%）、肌痛（55.0%）和关节痛（50.0%）。研究期间，5月（47.5%）和4月（35.0%）为旱季（无雨月份），MAYV病例最多。结论：这项研究在描述秘鲁安第斯地区卡哈马卡的MAYV存在方面是新颖的。症状无特异性，可与其他虫媒病毒或细菌感染的症状相混淆。RT-PCR等分子生物学方法可以及时、准确地检测MAYV，因此可被视为流行地区监测的一种工具。(C) 2020作者。由爱思唯尔有限公司代表国际传染病学会出版。
Background: The infection caused by Mayaro virus (MAYV), which presents as an acute febrile illness, is considered a neglected tropical disease. The virus is an endemic and emerging pathogen in South America and the Caribbean, responsible for occasional and poorly characterized outbreaks. Currently there is limited information about its expansion and risk areas.Methods: A cross-sectional study was performed in 10 urban primary care health centers in the Cajamarca region of Peru from January to June 2017. A total of 359 patients with suspected febrile illness were assessed. RNA was extracted from serum samples, following which MAYV real-time reverse transcriptase PCR (RT-PCR) for the detection of the nsP1 gene was performed.Results: MAYV was detected in 11.1% (40/359) of samples after RT-PCR amplification and confirmatory DNA sequencing. Most infections were detected in the adult population aged 18-39 years (40%) and 40-59 years (32.5%). Headache was the most frequent symptom in patients with MAYV infection (77.5%), followed by fever (72.5%), myalgia (55.0%), and arthralgia (50.0%). During the study, most of the MAYV cases were seen in May (47.5%) and April (35.0%), corresponding to the dry season (months without rain).Conclusions: This study is novel in describing the presence of MAYV in Cajamarca, an Andean region of Peru. Symptoms are non-specific and can be confused with those of other arbovirus or bacterial infections. Molecular biology methods such as RT-PCR allow the timely and accurate detection of MAYV and could thus be considered as a tool for surveillance in endemic areas. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.