Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetes
Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetes
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DOI：
10.1007/s00125-003-1292-4
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发表时间：
2004-02-01
期刊：
影响因子：
8.2
通讯作者：
Heller, SR
中科院分区：
文献类型：
--
作者：
Robinson, RTCE;Harris, ND;Heller, SR
目标/假设。实验性低血糖导致心脏复极异常，表现为QT间期延长，由肾上腺素能刺激引起。然而，目前还不太清楚自发的临床发作是否会导致类似的变化。因此，我们测量了1型糖尿病患者在低血糖和正常血糖夜间的心脏复极和逆调节反应。我们研究了22例1型糖尿病患者(平均年龄40.4+/-17.2岁，糖尿病病程17.2+/-9.3年，糖化血红蛋白8.2+/-1.2%)。每小时测量一次血糖、血钾、儿茶酚胺和高分辨率心电图。低血糖(血糖水平
Aims/hypothesis. Experimental hypoglycaemia leads to abnormal cardiac repolarization manifest by a lengthened QT interval and caused by adrenergic stimulation. However it is less clear whether spontaneous clinical episodes lead to similar changes. We have therefore measured cardiac ventricular repolarization and counterregulatory responses in patients with Type 1 diabetes during hypoglycaemic and euglycaemic nights.Methods. We studied 22 patients with Type 1 diabetes (mean age 40.4+/-17.2 years, duration of diabetes 17.2+/-9.3 years, HbA1c 8.2+/-1.2% overnight). Measurements were taken hourly of blood glucose, plasma potassium, catecholamines and high resolution electrocardiograms.Results. Hypoglycaemia (blood glucose level