Vulnerable neural systems and the borderland of brain aging and neurodegeneration.
Vulnerable neural systems and the borderland of brain aging and neurodegeneration.
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DOI：
10.1016/j.neuron.2013.01.002
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发表时间：
2013-01-23
期刊：
影响因子：
16.2
通讯作者：
Jagust W
中科院分区：
文献类型：
--
作者：
Jagust W
大脑老化的特征是相当大的异质性，包括特定大脑系统不同程度的功能障碍，特别是内侧颞叶记忆系统和额纹状体执行系统。这些系统也会受到晚年神经退行性疾病的影响。最近在认知正常的老年人中使用症状前疾病检测技术的研究表明，一些可归因于衰老的认知、神经结构和功能的晚年变化可能反映了早期的神经退化。然而，很明显，在没有细微疾病的情况下，这些大脑系统本身也很容易老化。因此，基本的系统性限制似乎赋予这些神经系统对各种侮辱的脆弱性，包括那些被认为是典型疾病的侮辱，以及那些被归因于年龄的侮辱。通过专注于神经系统脆弱性的根本原因，预防或治疗广泛的晚年神经功能障碍是可能的。
Brain aging is characterized by considerable heterogeneity, including varying degrees of dysfunction in specific brain systems, notably a medial temporal lobe memory system, and a frontostriatal executive system. These same systems are also affected by neurodegenerative diseases of late life. Recent work using techniques for presymptomatic detection of disease in cognitively normal older people has shown that some of the late life alterations in cognition, neural structure and function attributed to aging probably reflects early neurodegeneration. However, it has become clear that these same brain systems are also vulnerable to aging itself in the absence of even subtle disease. Thus, fundamental systemic limitations appear to confer vulnerability of these neural systems to a variety of insults, including those recognized as typical disease and those that are attributed to age. By focusing on the fundamental causes of neural system vulnerability, the prevention or treatment of a wide range of late-life neural dysfunction might be possible.
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期刊：
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