MYELIN-OLIGODENDROCYTE GLYCOPROTEIN (MOG) IS A SURFACE MARKER OF OLIGODENDROCYTE MATURATION
MYELIN-OLIGODENDROCYTE GLYCOPROTEIN (MOG) IS A SURFACE MARKER OF OLIGODENDROCYTE MATURATION
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DOI：
10.1016/0165-5728(89)90014-3
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发表时间：
1989-05-01
影响因子：
3.3
通讯作者：
COMPSTON, DAS
中科院分区：
文献类型：
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作者：
SCOLDING, NJ;FRITH, S;COMPSTON, DAS
髓磷脂-少突胶质细胞糖蛋白（MOG）是中枢神经系统髓磷脂的次要成分。利用月经大鼠视神经少突胶质细胞培养物，我们比较了 MOG 与半乳脑苷脂、髓磷脂碱性蛋白和 22'',3''-环核苷酸 3''-磷酸二酯酶的体外发育。 MOG 出现在少突胶质细胞表面的时间比其他少突胶质细胞标记物晚 1-2 天，这表明 MOG 可能是少突胶质细胞成熟的有用指标。讨论了这些发现与研究体外髓鞘损伤机制以及少突胶质细胞损伤在脱髓鞘疾病中的作用的相关性。
The myelin-oligodendrocyte glycoprotein (MOG) is a minor component of central nervous system myelin. Using menonatal rat optic nerve oligodendrocyte cultures we have compared the development in vitro of MOG with galactocerebroside, myelin basic protein and 22'',3''-cyclic-nucleotide 3''-phosphodiesterase. MOG appears on the surface of oligodendrocytes 1-2 days later than these other oligodendrocyte markers, suggesting that MOG may be usful indicator of oligodendrocyte maturation. The relevance of these findings for investigating mechanisms of myelin injury in vitor and the role of oligodendrocyte damage in demyelinating disease is discussed.