Emerging concepts of T cell metabolism as a target of immunotherapy.
Emerging concepts of T cell metabolism as a target of immunotherapy.
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DOI：
10.1038/ni.3415
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发表时间：
2016-04
影响因子：
30.5
通讯作者：
Pearce EL
中科院分区：
文献类型：
--
作者：
Chang CH;Pearce EL
新陈代谢是一组生化反应，使细胞能够获得和利用维持生命所需的营养。获取营养物质和满足新陈代谢需求是细胞生存、增殖和正常发挥预期功能所必需的。在免疫反应过程中，白细胞的生长和功能会发生重大变化，这与代谢过程的动态变化密切相关。免疫代谢是研究免疫和代谢过程之间相互作用的新兴领域。对这一领域的兴趣源于这样一种认识，即不正确的代谢重塑是许多异常免疫反应的基础，而且操纵细胞代谢可以有益地增强或缓和免疫。
Metabolism is the set of biochemical reactions that allows cells to acquire and utilize nutrients needed to sustain life. Accessing nutrients and meeting metabolic demands are necessary for cells to survive, proliferate, and to properly perform their intended functions. During an immune response leukocytes undergo major changes in growth and function that are tightly coupled to dynamic shifts in metabolic processes. Immunometabolism is an emerging field that investigates the interplay between immunological and metabolic processes. Interest in this field stems from the realization that incorrect metabolic remodeling underlies many aberrant immune responses, and that manipulating cellular metabolism can beneficially enhance or temper immunity.