The mRNA assembly line: transcription and processing machines in the same factory
The mRNA assembly line: transcription and processing machines in the same factory
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DOI：
10.1016/s0955-0674(02)00333-2
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发表时间：
2002-06-01
影响因子：
7.5
通讯作者：
Bentley, D
中科院分区：
文献类型：
--
作者：
Bentley, D
RNA 前体加工成成熟形式通常是共转录发生的。因此，DNA 模板、RNA 聚合酶和新生 RNA 链的三元复合物是通过加帽、剪接和切割/聚腺苷酸化修饰新生 RNA 的因子的生理底物。 mRNA 的生产被认为发生在包含 RNA 聚合酶 11 转录机和处理机的“工厂”内。新发现的 RNA 聚合酶和处理 mRNA 前体的因子之间的蛋白质-蛋白质联系开始阐明“mRNA 工厂”的工作原理。
Processing of RNA precursors to their mature form often occurs co-transcriptionally. Consequently, the ternary complex of DNA template, RNA polymerase and nascent RNA chain is the physiological substrate for factors that modify the nascent RNA by capping, splicing and cleavage/polyadenylation. mRNA production is thought to occur within a 'factory' that contains the RNA polymerase 11 transcription machine and the processing machines. Newly discovered protein-protein contacts between RNA polymerase and factors that process mRNA precursors are beginning to illuminate how the 'mRNA factory' works.