Percutaneous Double Lumen Cannula for Right Ventricle Assist Device System: A Computational Fluid Dynamics Study.
Percutaneous Double Lumen Cannula for Right Ventricle Assist Device System: A Computational Fluid Dynamics Study.
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DOI：
10.1016/j.bbe.2016.04.002
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发表时间：
2016
影响因子：
6.4
通讯作者：
Zwischenberger JB
中科院分区：
文献类型：
--
作者：
Condemi F;Wang D;Fragomeni G;Yang F;Zhao G;Jones C;Ballard-Croft C;Zwischenberger JB
我们的目标是开发一种用于经皮右心室辅助装置（pRVAD）的双腔套管（DLC），以消除RVAD安装和移除的两次开胸手术。本研究旨在评价pRVAD DLC的性能、流型、血液溶血和血栓形成潜力。使用有限体积法对pRVAD DLC进行计算流体动力学（CFD）。雷诺数小于4000时，采用层流模型描述血液流动行为，雷诺数大于4000时，采用剪切-应力输运k-ω模型描述血液流动行为。使用27 Fr原型进行了台架试验，以验证CFD计算。计算流体力学和实验压降结果之间的差异<1.3%。拉格朗日法显示在5 l/min流速下溶血指数较低（引流腔中为0.012%，输注腔中为0.0073%）。在CFD分析中发现了血液停滞和再循环区域，表明存在血栓形成的潜在风险。pRVAD DLC可处理高达5 l/min的流量，潜在溶血有限。需要进一步修改pRVAD DLC以解决血液停滞和再循环问题。
Our goal is to develop a double lumen cannula (DLC) for a percutaneous right ventricular assist device (pRVAD) in order to eliminate two open chest surgeries for RVAD installation and removal. The objective of this study was to evaluate the performance, flow pattern, blood hemolysis, and thrombosis potential of the pRVAD DLC. Computational fluid dynamics (CFD), using the finite volume method, was performed on the pRVAD DLC. For Reynolds numbers <4000, the laminar model was used to describe the blood flow behavior, while shear-stress transport k-ω model was used for Reynolds numbers >4000. Bench testing with a 27 Fr prototype was performed to validate the CFD calculations. There was <1.3% difference between the CFD and experimental pressure drop results. The Lagrangian approach revealed a low index of hemolysis (0.012% in drainage lumen and 0.0073% in infusion lumen) at 5 l/min flow rate. Blood stagnancy and recirculation regions were found in the CFD analysis, indicating a potential risk for thrombosis. The pRVAD DLC can handle up to 5 l/min flow with limited potential hemolysis. Further modification of the pRVAD DLC is needed to address blood stagnancy and recirculation.