DST non-suppression predicts suicide after attempted suicide
DST non-suppression predicts suicide after attempted suicide
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DOI：
10.1016/j.psychres.2006.12.001
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发表时间：
2007-04-15
影响因子：
11.3
通讯作者：
Nordstrom, Peter
中科院分区：
文献类型：
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作者：
Jokinen, Jussi;Carlborg, Andreas;Nordstrom, Peter
大多数HPA轴的前瞻性研究发现，地塞米松抑制试验（DST）中的非抑制者在随访期间更容易自杀。自杀未遂是自杀的临床预测因素。本研究的目的是评估DST对一组有和没有自杀企图指数的抑郁症住院患者自杀的预测价值。1980年至2000年间，卡罗林斯卡大学医院精神科收治的382名患有情绪障碍的精神病住院患者的历史队列被提交给DST，并对其死因进行了随访。在随访期间（平均18年），发生了36例自杀（9.4%），其中20例为无抑制性，16例为抑制性。在整个样本中，抑制者和非抑制者的自杀风险没有统计学上的显著差异。指数自杀企图预示着自杀。在有情绪障碍的自杀企图者中，非抑制状态与自杀显著相关，这表明下丘脑轴过度活跃是该组自杀的一个危险因素。地塞米松抑制试验可能是这一人群中有用的预测指标。2006爱思唯尔爱尔兰有限公司版权所有。
Most prospective studies of HPA axis have found that non-suppressors in the dexamethasone suppression test (DST) are more likely to commit suicide during the follow-up. Attempted suicide is a strong clinical predictor of suicide. The aim of this study was to assess the predictive value of DST for suicide in a group of depressed inpatients with and without an index suicide attempt. Historical cohort of 382 psychiatric inpatients with mood disorder admitted to the department of Psychiatry at the Karolinska University Hospital between 1980 and 2000 were submitted to the DST and followed up for causes of death. During the follow-up (mean 18 years), 36 suicides (9.4%) occurred, 20 of these were non-suppressors and 16 were suppressors. There was no statistically significant difference in suicide risk between the suppressors and non-suppressors for the sample as a whole. An index suicide attempt predicted suicide. In suicide attempters with mood disorder, the non-suppressor status was significantly associated with suicide indicating that HPA axis hyperactivity is a risk factor for suicide in this group. The dexamethasone suppression test may be a useful predictor within this population. (c) 2006 Elsevier Ireland Ltd. All rights reserved.