SEX-DIFFERENCES AND THE EFFECTS OF TAIL PINCH ON ETHANOL DRINKING IN MAUDSLEY RATS
SEX-DIFFERENCES AND THE EFFECTS OF TAIL PINCH ON ETHANOL DRINKING IN MAUDSLEY RATS
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DOI：
10.1016/0741-8329(95)00032-m
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发表时间：
1995-09-01
期刊：
影响因子：
2.3
通讯作者：
ADAMS, N
中科院分区：
文献类型：
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作者：
ADAMS, N
研究比较了10%乙醇（EtOH）和水的自愿消耗，在EtOH-naive，雄性和雌性莫兹利反应（MR）近交大鼠中，这些大鼠暴露于每天夹尾（TP）或无应激对照中连续35天。通过对10%的EtOH和水的偏好以及纯EtOH的摄入来衡量，女性喝的EtOH明显多于男性。暴露于TP的雌性在21天后对EtOH的偏好高于对照组，但在整个35天内没有差异。在测试的最后一周，与对照组相比，接触TP的男性倾向于喝更多的EtOH。实验2在上述条件下，将MR雌性与Maudsley非反应性（MNRA）雌性进行为期3周的比较；TP暴露增加了MR女性对EtOH的偏好，但在MNRA女性中没有。MR组的女性也明显比MNRA组的女性消耗更多的EtOH。在两项实验中，雌性大鼠在戒掉EtOH 6周后饮用的EtOH量与戒掉EtOH前的水平相当。在近亲繁殖的MR大鼠中发现的很大程度的变异性，对于开发一种模型来研究环境对遗传易感个体中EtOH滥用发展的影响具有重要意义。
Voluntary consumption of 10% ethanol (EtOH) vs. water was compared in EtOH-naive, male and female Maudsley Reactive (MR) inbred rats that were exposed to either daily episodes of tail pinch (TP), or no-stress controls for 35 consecutive days. Females drank significantly more EtOH than males as measured by preference for 10% EtOH vs. water, and for intake of pure EtOH. Females exposed to TP had a higher preference for EtOH relative to controls after 21 days, but there was no difference over the entire 35 days. Males exposed to TP tended to drink more EtOH during the last week of testing relative to controls. Experiment 2 compared MR females with Maudsley Nonreactive (MNRA) females for 3 weeks in the conditions described above; TP exposure increased EtOH preference in MR, but not in MNRA, females. MR females also consumed significantly more EtOH than MNRA females. In both experiments female rats drank amounts of EtOH following a 6-week period of EtOH abstinence comparable to their preabstinence levels. The large degree of variability found in inbred MR rats has implications for developing a model for the investigation of environmental influences on the development of EtOH abuse in genetically susceptible individuals.