Noninvasive interference tear meniscometry in dry eye patients with Sjogren syndrome
Noninvasive interference tear meniscometry in dry eye patients with Sjogren syndrome
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DOI：
10.1016/j.ajo.2007.04.006
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发表时间：
2007-08-01
影响因子：
4.2
通讯作者：
Tsubota, Kazuo
中科院分区：
文献类型：
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作者：
Uchida, Atsuro;Uchino, Miki;Tsubota, Kazuo
目得：比较非侵入性的泪液半月板高度（NI-TMH）使用泪液干扰装置在正常人和干燥综合征（SS）的干眼症患者，并探讨这种新方法的适用性之前和之后的泪点occlusion procedure.DESIGN：前瞻性病例对照study.METHODS：泪液半月板可视化非侵入性使用泪液干扰装置（Tearscope plus，Keeler，温莎，英国）。用连接到裂隙灯的数字摄像机（SP-321，JFC Sales Plan Co，Tokyo，Japan）捕获泪液干扰图像。利用图像分析软件测量下睑缘NI-TMH。对17例正常人28眼和27例SS患者46眼的NI-TMH进行比较。方法：对8例（11只眼）干眼患者行泪点阻塞术，观察术后3周NI-TMH的变化。正常人下睑缘NI-TMH为0.22 ± 0.065 mm，SS患者为0.13 ± 0.042 mm（P <0.0001）。泪点阻塞后，下眼睑边缘NI-TMH从0.12 +/- 0.026 mm显著增加至0.42 +/- 0.21 mm（P = 0.001）。在SS受试者中NI-TMH显著降低，并且在泪点阻塞后也显著改善。该方法有望在ATD干眼症（如SS）的诊断和泪点阻塞疗效评价方面有所帮助。
PURPOSE: To compare noninvasive tear meniscus height (NI-TMH) using a tear interference device in normal subjects and dry eye patients with Sjogren syndrome (SS), and to investigate the applicability of this new method before and after the punctal occlusion procedure.DESIGN: Prospective case control study.METHODS: Tear meniscus was visualized noninvasively using a tear interference device (Tearscope plus, Keeler, Windsor, United Kingdom). Tear interference image was captured with digital video camera (SP-321, JFC Sales Plan Co, Tokyo, Japan) attached to the slit-lamp. Lower lid margin NI-TMH was measured using image analysis software. NI-TMH of 28 eyes from 17 normal subjects and 46 eyes from 27 aqueous tear deficiency (ATD) dry eye patients with SS were compared. The change of NI-TMH three weeks after the successful punctal occlu sion was examined in 11 eyes of eight dry eye subjects.RESULTS: Tear meniscus was well visualized with the tear interference device in all cases. Lower lid margin NI-TMH was 0.22 +/- 0.065 mm in normal subjects, and 0.13 +/- 0.042 mm in SS subjects, respectively (P < .0001). After the punctal occlusion, lower lid margin NI-TMH increased significantly from 0.12 +/- 0.026 mm to 0.42 +/- 0.21 mm (P =.001).CONCLUSIONS. NI-TMH was substantially lower in SS subjects and also significantly improved after punctal occlusion. This method is expected to be helpful in the diagnosis and in the evaluation of the efficacy of punctal occlusion in ATD dry eyes such as SS.