Alterations in lipid profile of autistic boys: a case control study
Alterations in lipid profile of autistic boys: a case control study
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DOI：
10.1016/j.nutres.2010.04.002
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发表时间：
2010-04-01
影响因子：
4.5
通讯作者：
Kim, Eun Mi
中科院分区：
文献类型：
--
作者：
Kim, Eun-Kyung;Neggers, Yasmin H.;Kim, Eun Mi
我们假设自闭症与血浆脂质谱的改变有关，并且自闭症男孩的某些脂质成分可能与健康男孩显着不同。一项匹配的病例对照研究对从一所残疾儿童学校招募的 29 名自闭症男孩（平均年龄 10.1 +/- 1.3 岁）和从韩国邻近小学招募的 29 名健康男孩进行了匹配。测量空腹血浆总胆固醇（T-Chol）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、LDL/HDL比值和1天食物摄入量。进行多元回归分析以评估自闭症与各种脂质成分之间的关联。与对照组相比，病例组的平均 TO 水平（102.4 +/- 52.4 vs 70.6 +/- 36.3；P = .01）显着较高，而平均 HDL-C 水平（48.8 +/- 11.9 vs 60.5 +/- 10.9 mg/dL；P = .003）显着较低。病例和对照之间 T-Chol 和 LDL-C 水平没有显着差异。与对照组相比，病例中的 LDL/HDL 比率显着更高。多元回归分析表明，自闭症与血浆 TO（β = 31.7 +/- 11.9；P = .01）、HDL（β = 11.6 +/- 2.1；P = .0003）和 LDL/HDL 比率（β = 0.40 +/- 0.18；P = .04）显着相关。自闭症和 TO 水平与血浆 HDL 水平之间存在显着的交互作用 (P = .02)。血浆 HDL 中 53% 的变异可以通过自闭症、血浆 TG、LDL/HDL 比率以及自闭症和血浆 TO 水平之间的相互作用来解释。这些结果表明自闭症男孩存在血脂异常，并表明血脂异常可能是脂质代谢与自闭症之间关联的标志。 (C) 2010 Elsevier Inc. 保留所有权利。
We hypothesize that autism is associated with alterations in the plasma lipid profile and that some lipid fractions in autistic boys may be significantly different than those of healthy boys. A matched case control study was conducted with 29 autistic boys (mean age, 10.1 +/- 1.3 years) recruited from a school for disabled children and 29 comparable healthy boys from a neighboring elementary school in South Korea. Fasting plasma total cholesterol (T-Chol), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), the LDL/HDL ratio, and 1-day food intakes were measured. Multiple regression analyses were performed to assess the association between autism and various lipid fractions. The mean TO level (102.4 +/- 52.4 vs 70.6 +/- 36.3; P = .01) was significantly higher, whereas the mean HDL-C level (48.8 +/- 11.9 vs 60.5 +/- 10.9 mg/dL; P = .003) was significantly lower in cases as compared to controls. There was no significant difference in T-Chol and LDL-C levels between cases and controls. The LDL/HDL ratio was significantly higher in cases as compared to controls. Multiple regression analyses indicated that autism was significantly associated with plasma TO (beta = 31.7 +/- 11.9; P = .01), HDL (beta = 11.6 +/- 2.1; P = .0003), and the LDL/HDL ratio (beta = 0.40 +/- 0.18; P = .04). There was a significant interaction between autism and TO level in relation to plasma HDL level (P = .02). Fifty-three percent of variation in the plasma HDL was explained by autism, plasma TG, LDL/HDL ratio, and the interaction between autism and plasma TO level. These results indicate the presence of dyslipidemia in boys with autism and suggest a possibility that dyslipidemia might be a marker of association between lipid metabolism and autism. (C) 2010 Elsevier Inc. All rights reserved.