POTASSIUM ACCUMULATION IN INTERSTITIAL SPACE DURING EPILEPTIFORM SEIZURES
POTASSIUM ACCUMULATION IN INTERSTITIAL SPACE DURING EPILEPTIFORM SEIZURES
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DOI：
10.1016/0014-4886(70)90150-0
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发表时间：
1970-01-01
影响因子：
5.3
通讯作者：
RANCK, JB
中科院分区：
文献类型：
--
作者：
FERTZIGER, AP;RANCK, JB
本文研究了猫新皮质和大鼠海马区预加K42后，K42表面外流的变化。在所有电或扑热息痛诱发的癫痫和“自发”癫痫发作期间或之后，这种K42的外流从2倍增加到9倍。K42在癫痫发作期间不会改变，因此这种增加的流出不是由于扩散常数或脑内水流量的改变。外流的时间进程与简单地反映细胞钾周转增加的外流是不相容的。我们得出结论，癫痫发作期间，脑组织间隙中钾离子浓度升高。提出了一个模型，在这个模型中，钾的积累是癫痫发作启动的再生、全有或全无方面的重要步骤。
The K42surface efflux from the cat neocortex and rat hippocampus was studied after preloading with K42from the surface. This K42efflux increases from two to nine times during or after all electrically or Metrazol-induced seizures and “spontaneous” seizures. The K42influex does not change during a seizure, so this increased efflux is not due to change in the diffusion constant or water flow from brain. The time course of the efflux is not compatable with the efflux simply idicating increased turnover of potassium from cells. We conclude there is an increase in the concentration of potassium in the interstitial space during seizures. A model is proposed in which this potassium accumulation is an important step in the regenerative, all-or-none-aspect of the initiation of seizures.