Highly-efficient and versatile fluorous-tagged Cu(I)-catalyzed azide-alkyne cycloaddition ligand for preparing bioconjugates.
Highly-efficient and versatile fluorous-tagged Cu(I)-catalyzed azide-alkyne cycloaddition ligand for preparing bioconjugates.
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DOI：
10.1039/c5cc06858d
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发表时间：
2015-12-14
期刊：
影响因子：
--
通讯作者：
Zeng D
中科院分区：
文献类型：
--
作者：
Sun L;Gai Y;Anderson CJ;Zeng D
开发了一种新型配体（FBTTBE）用于Cu（I）催化的叠氮-炔环加成反应（CuAAC），它不仅表现出上级催化效率，而且易于去除有毒的铜物种。FBTTBE还成功地应用于放射性标记的肽和抗体的合成，而没有观察到与非放射性Cu（I）催化剂的螯合转移。
A novel ligand (FBTTBE) for Cu(I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(I) catalyst.