Fetal Origins of Hypertension
Fetal Origins of Hypertension
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DOI：
10.1007/978-981-10-5526-3_5
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Tsujita, Kenichi
中科院分区：
文献类型：
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作者：
Arima, Yuichiro;Nishiyama, Koichi;Tsujita, Kenichi
高血压是一种常见的非传染性疾病。根据世界卫生组织的数据，2015年有11.3亿人患有高血压。高血压，高血压，有多因素病因。动脉粥样硬化改变、心脏收缩或舒张功能障碍以及其他非心脏因素都涉及其中。流行病学证据显示，围产期生长障碍会增加高血压的患病率。然而，发育障碍对高血压病理过程的具体影响知之甚少。近年来，人们发现围产期在心血管发育中起着重要作用。在这一章中，我们专注于围产期发展的心血管系统，特别是在小鼠模型。在此期间，各个器官、血液、血管和心脏显示出独特的生长特征。我们还介绍了有关高血压发展起源的临床研究证据。最后，从几个动物模型的证据，揭示动脉病理发育障碍或压力的影响。提高我们对发育事件和临床研究结果的理解将使我们对高血压的胎儿起源有新的认识。
Hypertension is a common noncommunicable disease. According to the World Health Organization, 1.13 billion people were suffering from hypertension in the year 2015. High blood pressure, hypertension, has a multifactorial etiology. Arterial atherosclerotic changes, systolic or diastolic dysfunction of the heart, and other noncardiac factors are involved. Epidemiological evidence has revealed that perinatal growth disturbance elevates the prevalence of hypertension. However, the specific effects of developmental disturbances on the pathological process of hypertension are poorly understood. Recently, it has become apparent that the perinatal period plays many essential roles in cardiovascular development. In this chapter, we focus on the perinatal development of the cardiovascular system, especially in murine models. Individual organs, blood, blood vessels, and the heart show unique growth characteristics during this period. We also introduce evidence from related clinical studies regarding the developmental origins of hypertension. Finally, evidence from several animal models is presented to reveal the effects of developmental disturbance or stress on arterial pathology. Improving our understanding of both developmental events and the results of clinical studies will give fresh insight into the fetal origins of hypertension.