Concise review: Adult multipotent stromal cells and cancer: Risk or benefit?
Concise review: Adult multipotent stromal cells and cancer: Risk or benefit?
复制标题
DOI：
10.1634/stemcells.2007-1006
复制
发表时间：
2008-06-01
期刊：
影响因子：
5.2
通讯作者：
Jorgensen, Christian
中科院分区：
文献类型：
--
作者：
Lazennec, Gwendal;Jorgensen, Christian
间质细胞（MSCs）和癌症以及MSCs在基于细胞的抗癌治疗中的可能应用。间充质干细胞存在于多种组织中，被定义为具有多种分化能力的细胞，包括软骨细胞、成骨细胞和脂肪细胞。最近的证据还表明，它们可能在癌变的进展中发挥作用，并且MSCs可能向原发肿瘤和转移部位迁移。MSCs也可能通过自发转化参与癌变的早期阶段。此外，人们认为MSCs可以调节肿瘤的生长和转移，尽管这一问题仍然存在争议，也没有得到很好的理解。骨髓间充质干细胞的免疫抑制特性和促血管生成特性至少在一定程度上解释了它们对癌症发展的影响。另一方面，癌细胞也具有增强间充质干细胞迁移的能力。这种间充质干细胞和癌细胞之间的复杂对话对于肿瘤发展的结果无疑是至关重要的。有趣的是，一些研究表明，MSCs表达抗肿瘤因子可能是一种创新的选择，作为一种细胞介导的基因治疗来对抗肿瘤的生长。需要更多的证据来了解间充质干细胞如何积极或消极地调节癌变，并评估间充质干细胞在细胞介导的基因策略中使用的安全性。
stromal cells (MSCs) and carcinoma and the possible use of MSCs in cell-based anticancer therapies. MSCs are present in multiple tissues and are defined as cells displaying the ability to differentiate in multiple lineages, including chondrocytes, osteoblasts, and adipocytes. Recent evidence also suggests that they could play a role in the progression of carcinogenesis and that MSCs could migrate toward primary tumors and metastatic sites. It is possible that MSCs could also be involved in the early stages of carcinogenesis through spontaneous transformation. In addition, it is thought that MSCs can modulate tumor growth and metastasis, although this issue remains controversial and not well understood. The immunosuppressive properties and proangiogenic properties of MSCs account, at least in part, for their effects on cancer development. On the other hand, cancer cells also have the ability to enhance MSC migration. This complex dialog between MSCs and cancer cells is certainly critical for the outcome of tumor development. Interestingly, several studies have shown that MSCs engineered to express antitumor factors could be an innovative choice as a cell-mediated gene therapy to counteract tumor growth. More evidence will be needed to understand how MSCs positively or negatively modulate carcinogenesis and to evaluate the safety of MSC use in cell-mediated gene strategies.