Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection
Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection
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DOI：
10.1128/jcm.35.12.3320-3322.1997
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发表时间：
1997-12-01
影响因子：
9.4
通讯作者：
Ueda, T
中科院分区：
文献类型：
--
作者：
Iwasaki, H;Takada, N;Ueda, T
在恙虫病急性期，血清中巨噬细胞集落刺激因子（九名患者中的九名）和γ干扰素（九名患者中的六名）水平升高至正常范围以上。在五名患者的恢复期中观察到肿瘤坏死因子α水平显着升高，并且超过了急性期观察到的水平。高细胞因子血症似乎是恙虫病症状出现的原因。
Levels of macrophage colony-stimulating factor (nine of nine patients) and gamma interferon (six of nine patients) in serum were elevated above the range of normal in the acute phase of tsutsugamushi disease. Significant increases in levels of tumor necrosis factor alpha were observed during the convalescent phase in five patients, and they exceeded the levels observed during the acute phase, Hypercytokinemia appeared to be responsible for the emergence of the symptoms of tsutsugamushi disease.