Clinical outcomes in pregnant women with coronavirus disease 2019 in a perinatal medical center in Japan: a retrospective study of the first 1 year of the pandemic
Clinical outcomes in pregnant women with coronavirus disease 2019 in a perinatal medical center in Japan: a retrospective study of the first 1 year of the pandemic
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日本围产期医疗中心 2019 年冠状病毒病孕妇的临床结果：大流行前 1 年的回顾性研究
DOI：
10.1080/01443615.2022.2082277
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Okamoto A
中科院分区：
文献类型：
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作者：
Takahashi K;Kobayashi Y;Sato M;Nagae S;Kondo I;Funaki S;Sato T;Konishi A;Ito Y;Kamide T;Hoshina T;Kanuka H;Kobayashi M;Sakurai Y;Iwamoto M;Takahashi H;Samura O;Okamoto A
在这项回顾性研究中，我们分析了2020年4月至2021年4月期间在我们医院接受治疗的31名患有2019冠状病毒病（COVID-19）的孕妇的医疗记录的临床和人口统计数据。最常见的症状是发烧;约10%的患者无症状。1例肺炎迅速恶化的患者在30周时需要剖腹产，并入院接受重症监护。12例患者在我院接受围产期护理（10例活产，1例死胎，1例人工流产）。6例经阴道分娩，其余均经剖腹产分娩。2例患者出现并发症，包括重度高血压疾病和先兆子痫。所有患者均从COVID-19中康复。在任何患者的胎盘、脐带、脐带血、羊水、阴道液或母乳中均未检测到严重急性呼吸综合征冠状病毒2。无新生儿不良结局。冠状病毒传播到妊娠相关样本的可能性很低。影响声明关于这个问题，我们已经知道了什么？COVID-19以不同方式影响不同国家，COVID-19患者的发病率、死亡率和发病率因国家或地区和种族而异。这些结果的差异可能反映了种族差异和国家卫生保健系统的差异。此外，有关日本感染COVID-19的孕妇及其新生儿的围产期结局的信息有限。这项研究的结果对已知结果有何补充？我们描述了31名感染COVID-19的日本孕妇的围产期结局，这些孕妇在大流行的前1年在日本东京的围产期医疗中心接受了安全管理。这些发现对临床实践和/或进一步研究有何意义？尽管在我们的设施中没有观察到COVID-19阳性孕妇的孕产妇和新生儿死亡，但可能会发生严重的肺炎和围产期并发症。因此，重要的是要防止这种感染在怀孕期间提供有效的医疗护理。
In this retrospective study, we analysed clinical and demographic data from the medical records of 31 pregnant women with coronavirus disease 2019 (COVID-19) who were treated at our hospital between April 2020 and April 2021. The most common symptom was a fever; ∼10% of patients were asymptomatic. One patient with rapidly worsening pneumonia needed a Caesarean Section at 30 weeks and was admitted for intensive care. Twelve patients received perinatal care in our hospital (10 live births, one stillbirth, and one artificial abortion). Six patients delivered vaginally; the others deliveredviacaesarean section. Two patients had complications, including severe hypertensive disorders and preeclampsia. All patients recovered from COVID-19. Severe acute respiratory syndrome coronavirus 2 was not detected in the placenta, umbilical cord, cord blood, amniotic fluid, vaginal fluid, or breast milk in any patient. There were no neonatal adverse outcomes. The possibility of transmitting the coronavirus to pregnancy-related samples was low.IMPACT STATEMENTWhat is already known on the subject?COVID-19 has been affecting different countries in diverse ways, and the incidence, mortality, and morbidity rates of patients with COVID-19 vary widely by country or region and race. These differences in results may reflect racial differences and differences in national health care systems. Moreover, the information about the perinatal outcomes of pregnant women with COVID-19 and their newborns from Japan is limited.What do the results of this study add to what is known?We described the perinatal outcomes of 31 Japanese pregnant women with COVID-19 who were managed safely in a perinatal medical centre in Tokyo Japan, during the first 1 year of the pandemic.What are the implications of these findings for clinical practice and/or further research?Severe pneumonia and perinatal complications may occur, although no maternal and neonatal deaths were observed for COVID-19-positive pregnant women in our facility. Therefore, it is important to prevent this infection during pregnancy with the provision of effective medical care.