Regulation of Potassium Homeostasis
Regulation of Potassium Homeostasis
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DOI：
10.2215/cjn.08580813
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发表时间：
2015-06-01
影响因子：
9.8
通讯作者：
Palmer, Biff F.
中科院分区：
文献类型：
--
作者：
Palmer, Biff F.
钾离子是细胞内液中最丰富的阳离子，维持钾离子在细胞膜上的适当分布对正常细胞功能至关重要。钾体内平衡的长期维持是通过钾的肾脏排泄随摄入变化而改变来实现的。了解正常情况下钾的内部分布和肾脏清除的机制和调控影响，可以为临床实践中常见的钾疾病提供一个框架。本文综述了钾代谢正常调节的关键方面，旨在为知情的临床医生以及教学实习生和医学生提供方便查阅的综述。
Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper distribution of potassium across the cell membrane is critical for normal cell function. Long-term maintenance of potassium homeostasis is-achieved by alterations in renal excretion of potassium in response to variations in intake. Understanding the mechanism and regulatory influences governing the internal distribution and renal clearance of potassium under normal circumstances can provide a framework for approaching disorders of potassium commonly encountered in clinical practice. This paper reviews key aspects of the normal regulation of potassium metabolism and is designed to serve as a readily accessible review for the well informed clinician as well as a resource for teaching trainees and medical students.