Gut Bifidobacteria Populations in Human Health and Aging.
Gut Bifidobacteria Populations in Human Health and Aging.
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DOI：
10.3389/fmicb.2016.01204
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发表时间：
2016
影响因子：
5.2
通讯作者：
Ross RP
中科院分区：
文献类型：
--
作者：
Arboleya S;Watkins C;Stanton C;Ross RP
肠道微生物群越来越多地被证明在人类健康的各个方面发挥着重要作用。事实上，一些研究已经将肠道微生物群的改变与不同疾病的发展联系起来。在庞大的肠道细菌群落中，双歧杆菌是健康母乳喂养婴儿肠道中占主导地位的一个属，而在成年期，其水平较低但相对稳定。不同种类的双歧杆菌的存在随着年龄的变化而变化，从童年到老年。长双歧杆菌、B. breve和B.在婴儿中通常以两岐型为主，而B. catenulatum，小链藻B. B.和B一样。longum在成年人中更为普遍。越来越多的证据表明，补充双歧杆菌对改善人类健康状况具有有益作用，从防止感染到不同的肠外和肠内积极作用。此外，双歧杆菌与许多潜在的促进健康的代谢物的产生有关，包括短链脂肪酸、共轭亚油酸和细菌素。这篇小型综述的目的是描述与生命不同阶段相关的双歧杆菌组成变化，突出它们的有益作用，以及它们在许多疾病状态中的存在或不存在。
The intestinal microbiota has increasingly been shown to have a vital role in various aspects of human health. Indeed, several studies have linked alterations in the gut microbiota with the development of different diseases. Among the vast gut bacterial community, Bifidobacterium is a genus which dominates the intestine of healthy breast-fed infants whereas in adulthood the levels are lower but relatively stable. The presence of different species of bifidobacteria changes with age, from childhood to old age. Bifidobacterium longum, B. breve, and B. bifidum are generally dominant in infants, whereas B. catenulatum, B. adolescentis and, as well as B. longum are more prevalent in adults. Increasingly, evidence is accumulating which shows beneficial effects of supplementation with bifidobacteria for the improvement of human health conditions ranging from protection against infection to different extra- and intra-intestinal positive effects. Moreover, bifidobacteria have been associated with the production of a number of potentially health promoting metabolites including short chain fatty acids, conjugated linoleic acid and bacteriocins. The aim of this mini-review is to describe the bifidobacteria compositional changes associated with different stages in life, highlighting their beneficial role, as well as their presence or absence in many disease states.