Translational models for vascular cognitive impairment: a review including larger species.
Translational models for vascular cognitive impairment: a review including larger species.
复制标题
血管认知障碍的翻译模型：包括较大物种的综述。
DOI：
10.1186/s12916-017-0793-9
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发表时间：
2017-01-25
期刊：
影响因子：
9.3
通讯作者：
Troen AM
中科院分区：
文献类型：
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作者：
Hainsworth AH;Allan SM;Boltze J;Cunningham C;Farris C;Head E;Ihara M;Isaacs JD;Kalaria RN;Lesnik Oberstein SA;Moss MB;Nitzsche B;Rosenberg GA;Rutten JW;Salkovic-Petrisic M;Troen AM
疾病模型可用于病理学的前瞻性研究、分子和细胞机制的鉴定、干预措施的临床前测试以及临床生物标志物的验证。本文就血管性认知障碍的动物模型进行综述。专家从业人员首先介绍了每个模式的概要。概要由作者完善，随后由最近一次会议的科学委员会（2015年血管性痴呆国际会议）完善。只引用了同行审查的资料来源。我们纳入了模拟VCI相关脑病变（白色灌注不足损伤、局灶性缺血、脑淀粉样血管病）或再现VCI风险因素（老年、高血压、高同型半胱氨酸血症、高盐/高脂饮食）或再现VCI遗传原因（CADASIL引起的Notch 3突变）的模型。我们的结论是：（1）翻译模型可能反映了VCI相关的病理过程，但不能完全复制人类疾病谱;（2）VCI的啮齿动物模型受到白色物质缺乏的限制;（3）需要进一步的翻译模型和改进的认知测试工具。
Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited. We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension, hyperhomocysteinemia, high-salt/high-fat diet) or reproduce genetic causes of VCI (CADASIL-causing Notch3 mutations). We concluded that (1) translational models may reflect a VCI-relevant pathological process, while not fully replicating a human disease spectrum; (2) rodent models of VCI are limited by paucity of white matter; and (3) further translational models, and improved cognitive testing instruments, are required.