DEVELOPMENT OF TRACTION RETINAL DETACHMENTS FOLLOWING INTRAVITREAL INJECTIONS OF RETINAL MULLER AND PIGMENT EPITHELIAL-CELLS
DEVELOPMENT OF TRACTION RETINAL DETACHMENTS FOLLOWING INTRAVITREAL INJECTIONS OF RETINAL MULLER AND PIGMENT EPITHELIAL-CELLS
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DOI：
10.1007/bf02154745
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发表时间：
1986-01-01
影响因子：
2.7
通讯作者：
WILLIAMS, GA
中科院分区：
文献类型：
--
作者：
PETERS, MA;BURKE, JM;WILLIAMS, GA
在已建立的牵引性视网膜脱离模型中，我们将不同数量的视网膜Muller胶质细胞注射到兔玻璃体中。用间接眼底镜观察术后1个月的变化。虽然牵引性改变的严重程度随着神经胶质细胞数量的增加而增加，但在损伤后1周内病理变化趋于稳定。穆勒胶质细胞在诱导视网膜脱离方面不如视网膜色素上皮细胞(RPE)或胶质细胞和RPE的混合物。来源于胶质细胞的玻璃体内组织膜在形态上与来源于RPE的组织膜不同。3 H-胸腺嘧啶核苷放射自显影显示，胶质膜成纤维细胞样细胞较少，合成的细胞外基质较少，玻璃体内细胞增殖较低。我们的发现表明，与由RPE或混合细胞类型组成的膜相比，仅由Muller神经胶质细胞组成的膜促进视网膜病变不那么严重。
We injected varying numbers of retinal Muller glia into the rabbit vitreous in an established model of traction retinal detachment. We used indirect ophthalmoscopy to observe the changes elicited during the following 1 month. Although the severity of the tractional changes increased with increasing numbers of the glial cells, the pathology produced stabilized within the 1st week of injury. Muller glia were less effective at eliciting retinal detachments than retinal pigment epithelial cells (RPE) or mixtures of glia and RPE. Intravitreal tissue membranes derived from the glia differed morphologically from those derived from RPE. The glial membranes had fewer fibroblast-like cells, synthesized less extracelular matrix, and showed lower intravitreal cell proliferation, as determined by 3H-thymidine radioautography. Our findings indicate that membranes composed only of Muller glial cells promote less severe retinal pathology than those membranes composed of RPE or mixed cell types.