Control of virus-induced lymphoproliferation: Epstein-Barr virus-induced lymphoproliferation and host immunity.
Control of virus-induced lymphoproliferation: Epstein-Barr virus-induced lymphoproliferation and host immunity.
复制标题
病毒诱导的淋巴细胞增殖的控制：EB病毒诱导的淋巴细胞增殖和宿主免疫。
DOI：
10.1016/s1357-4310(96)10054-x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Heslop,HE
中科院分区：
文献类型：
--
作者：
Rooney,CM;Smith,CA;Heslop,HE
EB病毒(EBV)是一种潜伏的疱疹病毒，与许多肿瘤有关。EBV感染的细胞表现出三种潜伏期模式，从只表达一个EBV编码的抗原的1型到表达EBV编码的所有9个潜伏周期蛋白的3型。呈现3型潜伏期模式的恶性肿瘤是高度免疫原性的，仅在免疫功能低下的患者中发生。最近的研究表明，EBV特异性细胞毒性T淋巴细胞过继免疫治疗是治疗此类肿瘤的有效方法。提高肿瘤免疫原性的免疫治疗策略和方法目前正在对表现为2型潜伏期的肿瘤进行评估。
Epstein-Barr virus (EBV) is a latent herpesvirus that is associated with a number of tumors. EBV-infected cells show three patterns of latency ranging from type 1, where only one EBV-encoded antigen is expressed, to type 3, where all nine latent cycle proteins encoded by EBV are expressed. Malignancies exhibiting the type 3 latency pattern are highly immunogenic and occur only in immunocompromised patients. It has recently been shown that adoptive immunotherapy with EBV-specific cytotoxic T lymphocytes is an effective therapy for such tumors. Immunotherapy strategies and approaches to increase tumor immunogenicity are now being evaluated in tumors expressing type 2 latency.