Selenium status of preterm infants fed human milk, preterm formula, or selenium-supplemented preterm formula.
Selenium status of preterm infants fed human milk, preterm formula, or selenium-supplemented preterm formula.
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母乳、早产配方奶粉或补硒早产配方奶粉喂养的早产儿的硒状况。
DOI：
10.1016/s0022-3476(05)82058-x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Gardner,BR
中科院分区：
文献类型：
--
作者：
Smith,AM;Chan,GM;Moyer-Mileur,LJ;Johnson,CE;Gardner,BR
为探讨补硒效果，对46例口服维生素E充足早产儿(出生体重1700克)进行了3周纵向研究。婴儿喂养母乳(n=21；24 ng Se/ml)、早产配方奶粉(n=13；7.8 ng Se/ml)、或早产配方奶粉加亚硒酸钠(n=12；34.8 ng Se/ml)。在试验第1天(每日肠道饲喂达到100kcal/kg/d)和每周测定3周后，测定血浆和红细胞中硒和谷胱甘肽过氧化物酶活性以及尿硒和膳食硒含量。在整个研究过程中，喂食早产配方奶粉加亚硫酸钠的婴儿的硒摄入量高于喂食母乳的婴儿的摄入量，高于喂食早产配方奶粉的婴儿的硒摄入量(p<；0.001)。治疗3周后，各组大鼠血浆或红细胞内硒、谷胱甘肽过氧化物酶活性无明显差异。与报告的喂养母乳的足月儿相比，所有组的血浆硒和谷胱甘肽过氧化物酶的值都较低。喂养早产配方奶粉和亚硫酸钠的婴儿在第1周和第2周的尿硒水平高于服用早产配方奶粉的婴儿(p<；0.01)，而喂养母乳和早产配方奶粉的婴儿在第3周的尿硒水平低于研究第1天(p<；0.05)。我们的结论是，通常用于监测硒状况的血硒测量不能反映口服喂养的早产儿的膳食硒摄入量。
The selenium status of 46 orally fed vitamin E-sufficient preterm infants (birth weight <1700 gm) was studied longitudinally for 3 weeks to determine the efficacy of selenium supplementation. Infants were fed either human milk (n=21; 24 ng selenium/ml), preterm formula (n=13; 7.8 ng selenium/ml), or preterm formula supplemented with sodium selenite (n=12; 34.8 ng selenium/ml). Plasma and erythrocyte selenium and glutathione peroxidase activity and urinary and dietary selenium content were evaluated on study day 1 (day enteral feeds reached 100 kcal/kg/day) and weekly for 3 weeks. Throughout the study, selenium intakes of infants fed preterm formula plus sodium selenite were greater than those of infants fed human milk, which were greater than those of infants fed preterm formula (p<0.001). After 3 weeks no differences were observed among groups for plasma or erythrocyte selenium or glutathione peroxidase. Plasma selenium and glutathione peroxidase values within all groups were low compared with those reported for term infants fed human milk. Whereas urinary selenium levels of infants fed preterm formula plus sodium selenite were greater than those of infants fed preterm formula at weeks 1 and 2 (p<0.01), infants fed human milk and preterm formula had lower levels at week 3 than on study day 1 (p<0.05). We conclude that blood selenium measurements typically used to monitor selenium status do not reflect dietary selenium intakes of orally fed preterm infants.