Understanding salivary fluid and protein secretion
Understanding salivary fluid and protein secretion
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DOI：
10.1034/j.1601-0825.2002.10815.x
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发表时间：
2002-01-01
期刊：
影响因子：
3.8
通讯作者：
Sugiya, H
中科院分区：
文献类型：
--
作者：
Turner, RJ;Sugiya, H
Mammalian salivary glands are mainly composed of two epithelial cell types, the acinar cells that secrete the salivary fluid as well as most of the salivary proteins, and the ductal cells that secrete some protein and modify the ionic composition of the saliva as they convey it to the mouth. For a variety of reasons, including their physiological interest, their relative abundance and ease of preparation, and their robust stimulation-secretion responses, salivary acinar cells been intensively studied and many of their properties are well, albeit certainly not completely, understood. Although salivary ducts have also received considerable experimental attention, particularly over the past 10 years, less is known about their behavior. Because of this and because of the central role of the acinar cells in salivary fluid and protein secretion we will concentrate almost exclusively on them in this article. For more information on salivary ducts the interested reader is referred to several recent reviews and the references therein (Cook et al, 1994; Young and Cook, 1996; Cook et al, 1998). It is also worth mentioning at this point that most of the information presented below has been obtained from the salivary glands of experimental animals (mainly rats and rabbits). Except for morphologic studies and several non-invasive procedures, such as the collection of saliva after the application of various stimuli, experiments using human salivary tissues are rare. However, in those cases where the functional properties of human salivary acini have been investigated they appear to conform well to the results and conclusions derived from animal studies.
