Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans
Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans
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DOI：
10.4077/cjp.2018.bah587
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发表时间：
2018-06-30
影响因子：
1.8
通讯作者：
Huang, Chi-Chang
中科院分区：
文献类型：
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作者：
Huang, Wen-Ching;Hsu, Yi-Ju;Huang, Chi-Chang
微生物区系是当前疾病和健康中的一个重要问题，许多研究表明它在生理动态平衡和促进健康方面发挥着重要作用。植物乳杆菌是从台湾腌制蔬菜中分离到的一种广为人知的益生菌。最近的一项动物研究表明，补充植物乳杆菌TWK10(TWK10)可以增加小鼠的肌肉质量，改善运动能力，并起到抗疲劳的作用。为了检验补充TWK10对人类耐力表现的递增效应，我们进行了一项人类双盲安慰剂对照临床研究。总共招募了16名20岁以上的成年受试者，并随机分配到安慰剂组或TWK10组(n=8)。TWK10组接受6周的补充。生理评价采用力竭性平板运动测量及相关生化指标。补充6周后，测定力竭运动时的血乳酸、血氨、血糖、游离脂肪酸(FFA)和肌酸激酶(CK)水平。我们能够证明，TWK10组的耐力表现和最大跑台跑试验中的葡萄糖含量显著高于安慰剂组(P<；0.05)，这表明补充TWK10可能有利于能量的获取。综上所述，我们的结果表明，TWK10有可能成为一种用于生理适应的有氧运动补充剂，或者是一种对业余跑步者健康有益的增补剂。
Microbiota is currently an important issue in disease and health and many studies have revealed it to play an important role in physiological homeostasis and health promotion. Lactobacillus plantarum (L. plantarum), isolated from Taiwan pickled vegetables, is a well-known probiotic microorganism. In a recent animal study, it was shown that supplementation of mice with L. plantarum TWK10 (TWK10) could increase muscle mass, improve exercise performance and exert anti-fatigue effects. In order to examine the ergogenic effect of TWK10 supplementation on endurance performance in humans, we conducted a human double-blind placebo-controlled clinical study. A total of sixteen adult subjects over 20 years of age were recruited and randomly allocated to the placebo or TWK10 group (n = 8 each). The TWK10 group received 6 weeks of supplementation. Physiological assessments were conducted by exhaustive treadmill exercise measurements and related biochemical indexes. After 6 weeks of supplementation, levels of lactic acid, blood ammonia, blood glucose, free fatty acid (FFA) and creatine kinase (CK) were evaluated during exhaustive exercise. We were able to show that the TWK10 group had significantly higher endurance performance and glucose content in a maximal treadmill running test compared to the placebo group (P < 0.05), suggesting that TWK10 supplementation may be beneficial to energy harvest. Taken together, our results suggest that TWK10 has the' potential to he an aerobic exercise supplement for physiological adaptation or an ergogenic supplement with health benefits for amateur runners.