Accuracy of micro powder dosing via a vibratory sieve-chute system
Accuracy of micro powder dosing via a vibratory sieve-chute system
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DOI：
10.1016/j.ejpb.2015.04.037
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发表时间：
2015-08-01
影响因子：
4.9
通讯作者：
Khinast, J. G.
中科院分区：
文献类型：
--
作者：
Besenhard, M. O.;Faulhammer, E.;Khinast, J. G.
本文描述了一种粉末计量系统，该系统将振动筛安装在溜槽上，将颗粒计量到胶囊中。垂直振动发生的频率和幅度范围很大。在给药过程中，通过电容传感器准确记录灌装重量，覆盖胶囊，从而可以分析灌装特性，即灌装率及其稳健性。对频率和幅度的范围进行筛选，以确定有利于三种乳糖粉的合理(无堵塞、无溢出)灌装率的设置。在此工作空间内研究了充填特性。结果表明，所有被研究的粉末的工作空间都是相似的。填充率稳健性在操作空间中有明显的变化，这对于选择连续进料应用的设置至关重要。此外，我们还利用有关每种粉末的填充特性的知识进行了精确的配料研究。(C)2015爱思唯尔B.V.保留所有权利。
This paper describes a powder dosing system with a vibratory sieve mounted on a chute that doses particles into a capsule. Vertical vibration occurred with a broad range of frequencies and amplitudes. During dosing events, the fill weight was accurately recorded via a capacitance sensor, covering the capsules and making it possible to analyze filling characteristics, that is, the fill rates and their robustness. The range of frequencies and amplitudes was screened for settings that facilitated reasonable (no blocking, no spilling) fill rates for three lactose powders. The filling characteristics were studied within this operating space. The results reveal similar operating spaces for all investigated powders. The fill rate robustness varied distinctly in the operating space, which is of prime importance for selecting the settings for continuous feeding applications. In addition, we present accurate dosing studies utilizing the knowledge about the filling characteristics of each powder. (C) 2015 Elsevier B.V. All rights reserved.