COLLATERALS OF SPINOTHALAMIC TRACT CELLS TO THE PERIAQUEDUCTAL GRAY - A FLUORESCENT DOUBLE-LABELING STUDY IN THE RAT
COLLATERALS OF SPINOTHALAMIC TRACT CELLS TO THE PERIAQUEDUCTAL GRAY - A FLUORESCENT DOUBLE-LABELING STUDY IN THE RAT
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DOI：
10.1016/0006-8993(88)91386-8
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发表时间：
1988-02-16
期刊：
影响因子：
2.9
通讯作者：
WILLIS, WD
中科院分区：
文献类型：
--
作者：
HARMANN, PA;CARLTON, SM;WILLIS, WD
本实验观察了大鼠脊髓丘脑束（STT）细胞在丘脑腹基底核（VB）和外侧导水管周围灰质（PAG）的分布。将两种逆行转运的荧光染料（二脒基黄和颗粒蓝）注射到每只动物中。在颈、胸、腰和骶脊髓中绘制单标记和双标记细胞的分布。平均1.4%的STT细胞和6.2%的PAG细胞投射到VB丘脑和PAG。双标记细胞仅在脊髓的颈段和腰段观察到，在颈膨大处发现的数量最多。双标细胞位于第I、V层和脊髓外侧核。在这3个区域中发现的双标记细胞的数量根据脊髓水平而变化。这群显示侧支的神经元提供了一种解剖学机制，通过这种机制，有害刺激不仅激活丘脑中的神经元，而且激活PAG中的神经元，PAG是参与刺激产生的镇痛（SPA）的区域。
Spinothalamic tract (STT) cells were investigated in the rat to determine the distribution of STT cells with terminals in both the ventrobasal (VB) thalamus and the lateral periaqueductal gray (PAG). Two retrogradely transported fluorescent dyes (Diamidino yellow and Granular blue) were injected into each animal. The distribution of single- and double-labeled cells was mapped in the cervical, thoracic, lumbar and sacral spinal cord. An average of 1.4% of all STT cells and 6.2% of PAG cells projected to both VB thalamus and PAG. Double-labeled cells were observed only in cervical and lumbar levels of the spinal cord, with the greatest number found in the cervical enlargement. The double-labeled cells were located in laminae I and V and also in the lateral spinal nucleus (LSN). The number of double-labeled cells found in each of these 3 areas varied depending on the spinal cord level. This population of neurons exhibiting collaterals provide an anatomical mechanism by which noxious stimuli activate neurons not only in the thalamus but also in the PAG, which is an area involved in stimulation-produced analgesia (SPA).